6JD8
Structure of a proline specific mutant of human cathepsin L
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin L1 | polymer | 360 | 40918.4 | 1 | UniProt (P07711) Pfam (PF08246) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin L,Major excreted protein,MEP |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C, D, E, F, G... (A) | ETHANOL | non-polymer | 46.1 | 12 | Chemie (EOH) | |||
| 4 | O (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | P (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | Q (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | R (A) | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 1 - 316 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Met -43 | - | expression tag |
| His -42 | - | expression tag |
| His -41 | - | expression tag |
| His -40 | - | expression tag |
| His -39 | - | expression tag |
| His -38 | - | expression tag |
| His -37 | - | expression tag |
| Ser -36 | - | expression tag |
| Ser -35 | - | expression tag |
| Gly -34 | - | expression tag |
| Leu -33 | - | expression tag |
| Val -32 | - | expression tag |
| Pro -31 | - | expression tag |
| Arg -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Ser -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Met -26 | - | expression tag |
| Lys -25 | - | expression tag |
| Glu -24 | - | expression tag |
| Thr -23 | - | expression tag |
| Ala -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Lys -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Arg -16 | - | expression tag |
| Gln -15 | - | expression tag |
| His -14 | - | expression tag |
| Met -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Thr -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ser 121 | Cys 138 | engineered mutation |
| Tyr 165 | Leu 182 | engineered mutation |
| Leu 257 | Met 274 | engineered mutation |
| Ala 260 | Gly 277 | engineered mutation |
| Leu 310 | Ala 327 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40918.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 963.3 | |
| All* | Total formula weight | 41881.7 |
