6JD8
Structure of a proline specific mutant of human cathepsin L
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005764 | cellular_component | lysosome |
| A | 0005771 | cellular_component | multivesicular body |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006955 | biological_process | immune response |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008656 | molecular_function | cysteine-type endopeptidase activator activity involved in apoptotic process |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016540 | biological_process | protein autoprocessing |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0019065 | biological_process | receptor-mediated endocytosis of virus by host cell |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031638 | biological_process | zymogen activation |
| A | 0034230 | biological_process | enkephalin processing |
| A | 0036021 | cellular_component | endolysosome lumen |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0042393 | molecular_function | histone binding |
| A | 0042583 | cellular_component | chromaffin granule |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0043373 | biological_process | CD4-positive, alpha-beta T cell lineage commitment |
| A | 0043394 | molecular_function | proteoglycan binding |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0048002 | biological_process | antigen processing and presentation of peptide antigen |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 0060309 | biological_process | elastin catabolic process |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| A | 0071888 | biological_process | macrophage apoptotic process |
| A | 0097067 | biological_process | cellular response to thyroid hormone stimulus |
| A | 0097655 | molecular_function | serpin family protein binding |
| A | 2001235 | biological_process | positive regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | PHE135 |
| A | GLY139 |
| A | ARG140 |
| A | LEU141 |
| A | HOH507 |
| A | HOH536 |
| A | HOH601 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 402 |
| Chain | Residue |
| A | HOH524 |
| A | ASP300 |
| A | ARG302 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EOH A 403 |
| Chain | Residue |
| A | GLU159 |
| A | ASN162 |
| A | GLY163 |
| A | TYR165 |
| A | SER270 |
| A | THR271 |
| A | HOH572 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EOH A 404 |
| Chain | Residue |
| A | GLU51 |
| A | LYS53 |
| A | LEU93 |
| A | VAL202 |
| A | HOH591 |
| A | HOH597 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EOH A 405 |
| Chain | Residue |
| A | LYS87 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EOH A 406 |
| Chain | Residue |
| A | GLY116 |
| A | GLN117 |
| A | ALA189 |
| A | EDO415 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EOH A 407 |
| Chain | Residue |
| A | GLY154 |
| A | ASN158 |
| A | GLU159 |
| A | GLY160 |
| A | GLU191 |
| A | HOH537 |
| A | HOH546 |
| A | HOH586 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 408 |
| Chain | Residue |
| A | ASN38 |
| A | SER68 |
| A | GLU237 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EOH A 409 |
| Chain | Residue |
| A | LYS87 |
| A | CYS194 |
| A | TYR196 |
| A | THR206 |
| A | HOH532 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 410 |
| Chain | Residue |
| A | THR1 |
| A | THR3 |
| A | PHE4 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EOH A 411 |
| Chain | Residue |
| A | GLU28 |
| A | ARG32 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EOH A 412 |
| Chain | Residue |
| A | LYS113 |
| A | SER143 |
| A | GLU182 |
| A | HOH559 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EOH A 413 |
| Chain | Residue |
| A | PHE124 |
| A | GLU146 |
| A | GLU182 |
| A | TYR187 |
| A | HOH602 |
| A | HOH692 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 414 |
| Chain | Residue |
| A | ASP205 |
| A | THR206 |
| A | HOH542 |
| A | HOH547 |
| A | HOH624 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | TYR187 |
| A | GLN214 |
| A | EOH406 |
| A | HOH584 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue PGE A 416 |
| Chain | Residue |
| A | VAL74 |
| A | MET75 |
| A | ASN76 |
| A | GLY77 |
| A | PHE78 |
| A | GLN115 |
| A | GLY119 |
| A | SER120 |
| A | SER121 |
| A | GLY163 |
| A | GLY164 |
| A | ASP258 |
| A | HIS259 |
| A | THR271 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LDHAVLVVGYG |
| Chain | Residue | Details |
| A | LEU257-GLY267 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR278-MET297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:9468501 |
| Chain | Residue | Details |
| A | SER121 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | HIS259 | |
| A | ASN283 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:9468501 |
| Chain | Residue | Details |
| A | PHE89 | |
| A | GLN90 | |
| A | TYR95 | |
| A | GLU96 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN204 |
