6IS0
Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PDX1 C-terminal-inhibiting factor 1 | polymer | 496 | 57570.8 | 1 | UniProt (A0A0R4IKJ1) Pfam (PF12237) | Danio rerio (Zebrafish) | |
| 2 | B (C) | m7G-capped RNA | polymer | 3 | 1083.7 | 1 | synthetic construct | ||
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | D (A) | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE | non-polymer | 458.2 | 1 | Chemie (M7G) | |||
| 5 | E, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | I (A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 7 | J, K (A, C) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A: 178 - 673 (UniProt: A0A0R4IKJ1)
| PDB | External Database | Details |
|---|---|---|
| Val 308 | Ala 308 | engineered mutation |
| Asn 344 | His 344 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58654.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1373.3 | |
| All* | Total formula weight | 60027.7 |
