6IS0
Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue SAH A 701 |
| Chain | Residue |
| A | SER497 |
| A | CYS529 |
| A | SER530 |
| A | PRO544 |
| A | PHE545 |
| A | GLU556 |
| A | ASN558 |
| A | PRO560 |
| A | EDO706 |
| A | HOH809 |
| A | HOH846 |
| A | LEU498 |
| A | HOH918 |
| A | HOH1030 |
| A | PHE503 |
| A | GLU515 |
| A | CYS516 |
| A | PHE517 |
| A | ALA518 |
| A | SER519 |
| A | ASN522 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue M7G A 702 |
| Chain | Residue |
| A | ARG239 |
| A | ARG269 |
| A | GLU563 |
| A | TRP593 |
| A | ASP595 |
| A | PRO596 |
| A | PRO597 |
| A | THR598 |
| A | HOH839 |
| A | HOH877 |
| A | HOH926 |
| A | HOH953 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 703 |
| Chain | Residue |
| A | HIS198 |
| A | LEU251 |
| A | PRO253 |
| A | HOH841 |
| A | HOH891 |
| A | HOH917 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 704 |
| Chain | Residue |
| A | LEU241 |
| A | LYS245 |
| A | PRO253 |
| A | LEU254 |
| A | ALA531 |
| A | PHE532 |
| A | HOH809 |
| A | HOH909 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 705 |
| Chain | Residue |
| A | PRO201 |
| A | HIS202 |
| A | PRO203 |
| A | PRO419 |
| A | PRO420 |
| A | LYS468 |
| A | SER471 |
| A | HOH939 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | ASN558 |
| A | PRO559 |
| A | PRO560 |
| A | PHE561 |
| A | SAH701 |
| A | HOH820 |
| A | HOH836 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue B3P A 707 |
| Chain | Residue |
| A | GLU192 |
| A | ARG193 |
| A | ALA194 |
| A | PRO195 |
| A | GLU401 |
| A | VAL402 |
| A | GLN403 |
| A | ASP404 |
| A | ARG405 |
| A | TYR410 |
| A | PRO501 |
| A | GLU504 |
| A | GLU620 |
| A | HOH827 |
| A | HOH857 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for residues M7G C 1 and A2M C 2 |
| Chain | Residue |
| A | VAL178 |
| A | TYR179 |
| A | ARG191 |
| A | LYS285 |
| A | SER334 |
| A | LYS335 |
| A | GLU374 |
| A | ARG377 |
| A | ARG378 |
| A | ASP404 |
| A | ARG405 |
| A | LEU406 |
| A | ASP431 |
| A | ARG446 |
| A | VAL500 |
| A | GLU622 |
| A | TYR623 |
| A | ARG624 |
| C | G3 |
| C | HOH101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30467178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30467178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IS0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
