6IMZ
Crystal structure of MTH1 in complex with 18-Crown-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 163 | 18985.6 | 1 | UniProt (P36639) Pfam (PF00293) | Homo sapiens (Human) | 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
| 2 | B, C, G (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, H (A) | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 2 | Chemie (O4B) | |||
| 5 | F (A) | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | non-polymer | 450.3 | 1 | Chemie (VGH) | |||
| 6 | I (A) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 3 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| Leu 157 | - | expression tag |
| Glu 158 | - | expression tag |
| His 159 | - | expression tag |
| His 160 | - | expression tag |
| His 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18985.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1271.3 | |
| All* | Total formula weight | 20256.8 |
