6IMZ
Crystal structure of MTH1 in complex with 18-Crown-6
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001669 | cellular_component | acrosomal vesicle |
A | 0003723 | molecular_function | RNA binding |
A | 0005515 | molecular_function | protein binding |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005829 | cellular_component | cytosol |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006281 | biological_process | DNA repair |
A | 0006979 | biological_process | response to oxidative stress |
A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
A | 0008584 | biological_process | male gonad development |
A | 0008828 | molecular_function | dATP diphosphatase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016818 | molecular_function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
A | 0030515 | molecular_function | snoRNA binding |
A | 0031965 | cellular_component | nuclear membrane |
A | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
A | 0042262 | biological_process | DNA protection |
A | 0046686 | biological_process | response to cadmium ion |
A | 0046872 | molecular_function | metal ion binding |
A | 0047693 | molecular_function | ATP diphosphatase activity |
A | 0106377 | molecular_function | 2-hydroxy-ATP hydrolase activity |
A | 0106378 | molecular_function | 2-hydroxy-dATP hydrolase activity |
A | 0106431 | molecular_function | N6-methyl-(d)ATP hydrolase activity |
A | 0106433 | molecular_function | O6-methyl-dGTP hydrolase activity |
A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 201 |
Chain | Residue |
A | ASP82 |
A | HIS84 |
A | HIS159 |
A | HIS161 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 202 |
Chain | Residue |
A | GLU41 |
A | HIS162 |
A | HIS163 |
A | HIS164 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 203 |
Chain | Residue |
A | HIS161 |
A | HIS162 |
A | HIS162 |
A | HIS163 |
A | HIS163 |
A | HIS164 |
A | HIS161 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue O4B A 204 |
Chain | Residue |
A | GLU73 |
A | VAL75 |
A | GLY76 |
A | LYS138 |
A | ASP147 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue VGH A 205 |
Chain | Residue |
A | TYR7 |
A | LEU9 |
A | PHE27 |
A | PHE72 |
A | PHE74 |
A | MET81 |
A | VAL83 |
A | TRP117 |
A | ASP119 |
A | GLN142 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue ZN A 206 |
Chain | Residue |
A | HIS65 |
A | CYS87 |
A | HOH353 |
site_id | AC7 |
Number of Residues | 10 |
Details | binding site for residue O4B A 207 |
Chain | Residue |
A | TYR122 |
A | PRO125 |
A | LEU126 |
A | GLN129 |
A | GLN129 |
A | LYS130 |
A | LYS131 |
A | LEU150 |
A | GLU152 |
A | GLU152 |
Functional Information from PROSITE/UniProt
site_id | PS00893 |
Number of Residues | 22 |
Details | NUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG |
Chain | Residue | Details |
A | GLY37-GLY58 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3 |
Chain | Residue | Details |
A | LEU11 | |
A | GLN14 | |
A | PRO15 | |
A | LEU59 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM |
Chain | Residue | Details |
A | GLY76 |