6IJY
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 8-oxo-dGTP determined using a crystal obtained under microgravity
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 156 | 17995.5 | 2 | UniProt (P36639) Pfam (PF00293) In PDB | Homo sapiens (Human) | 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
2 | A, B | 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (8DG) | |||
3 | A, B | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
PDB | External Database | Details |
---|---|---|
Lys 2 | Gly 43 | engineered mutation |
Ala 87 | Cys 128 | engineered mutation |
Ser 104 | Cys 145 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 35990.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1322.5 | |
All* | Total formula weight | 37313.4 |