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6IJY

Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 8-oxo-dGTP determined using a crystal obtained under microgravity

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue 8DG A 201
ChainResidue
ATYR7
ALYS38
AGLU56
APHE72
AMET81
ATRP117
AASP119
AASP120
ATRP123
ANA202
ANA204
ATHR8
AHOH311
AHOH314
AHOH326
AHOH331
AHOH336
AHOH363
AHOH381
AHOH390
AHOH405
BLYS130
ALEU9
ALYS23
AARG25
APHE27
AASN33
AGLY36
AGLY37

site_idAC2
Number of Residues5
Detailsbinding site for residue NA A 202
ChainResidue
AGLY36
AGLU56
A8DG201
ANA204
AHOH395

site_idAC3
Number of Residues4
Detailsbinding site for residue NA A 203
ChainResidue
APHE113
AMET116
AHOH388
BHOH411

site_idAC4
Number of Residues7
Detailsbinding site for residue NA A 204
ChainResidue
AGLU52
AGLU56
A8DG201
ANA202
AHOH303
AHOH311
AHOH314

site_idAC5
Number of Residues7
Detailsbinding site for residue GOL A 205
ChainResidue
ALYS2
AVAL75
AGLY76
ASER121
ATYR122
AHOH456
BHOH320

site_idAC6
Number of Residues8
Detailsbinding site for residue GOL A 206
ChainResidue
AHOH426
BLYS2
BGLU73
BVAL75
BGLY76
BGLU77
BTYR122
BHOH452

site_idAC7
Number of Residues28
Detailsbinding site for residue 8DG B 201
ChainResidue
ALYS130
AHOH309
AHOH320
AHOH325
AHOH385
BTYR7
BTHR8
BLEU9
BASN33
BGLY36
BGLY37
BLYS38
BGLU52
BGLU56
BPHE72
BPHE74
BMET81
BTRP117
BASP119
BASP120
BTRP123
BPHE139
BNA202
BHOH313
BHOH316
BHOH342
BHOH343
BHOH344

site_idAC8
Number of Residues5
Detailsbinding site for residue NA B 202
ChainResidue
BTRP117
BASP119
BASP120
B8DG201
BHOH343

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
ALEU11
AGLN14
APRO15
ALEU59
BLEU11
BGLN14
BPRO15
BLEU59

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM
ChainResidueDetails
AGLY76
BGLY76

226707

PDB entries from 2024-10-30

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