6IF3

Complex structure of Rab35 and its effector ACAP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2	polymer	174	19000.1	1	UniProt (Q15057) Pfam (PF12796) In PDB	Homo sapiens (Human)	Centaurin-beta-2,Cnt-b2
2	B	Ras-related protein Rab-35	polymer	186	21095.9	1	UniProt (Q15286) Pfam (PF00071) In PDB	Homo sapiens (Human)	GTP-binding protein RAY,Ras-related protein Rab-1C
3	B	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
4	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5		water	water		18.0	390	Chemie (HOH)

Sequence modifications

A: 601 - 770 (UniProt: Q15057)

PDB	External Database	Details
Gly 597	-	expression tag
Pro 598	-	expression tag
Gly 599	-	expression tag
Ser 600	-	expression tag

B: 1 - 180 (UniProt: Q15286)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Leu 67	Gln 67	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40096.0
Non-Polymers*	Number of molecules	2
	Total formula weight	547.5
All*	Total formula weight	40643.5

*Water molecules are not included.