6IF3
Complex structure of Rab35 and its effector ACAP2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000281 | biological_process | mitotic cytokinesis |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| B | 0005768 | cellular_component | endosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005905 | cellular_component | clathrin-coated pit |
| B | 0008104 | biological_process | intracellular protein localization |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015031 | biological_process | protein transport |
| B | 0016197 | biological_process | endosomal transport |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0030136 | cellular_component | clathrin-coated vesicle |
| B | 0030669 | cellular_component | clathrin-coated endocytic vesicle membrane |
| B | 0031175 | biological_process | neuron projection development |
| B | 0031253 | cellular_component | cell projection membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0032456 | biological_process | endocytic recycling |
| B | 0036010 | biological_process | protein localization to endosome |
| B | 0042470 | cellular_component | melanosome |
| B | 0045171 | cellular_component | intercellular bridge |
| B | 0045334 | cellular_component | clathrin-coated endocytic vesicle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048227 | biological_process | plasma membrane to endosome transport |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1990090 | biological_process | cellular response to nerve growth factor stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue GTP B 201 |
| Chain | Residue |
| B | SER17 |
| B | TYR37 |
| B | THR40 |
| B | GLY66 |
| B | ASN120 |
| B | LYS121 |
| B | ASP123 |
| B | SER150 |
| B | ALA151 |
| B | LYS152 |
| B | MG202 |
| B | GLY18 |
| B | HOH301 |
| B | HOH322 |
| B | HOH327 |
| B | HOH332 |
| B | HOH333 |
| B | HOH410 |
| B | HOH437 |
| B | VAL19 |
| B | GLY20 |
| B | LYS21 |
| B | SER22 |
| B | SER23 |
| B | PHE33 |
| B | GLY35 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | SER22 |
| B | THR40 |
| B | GTP201 |
| B | HOH322 |
| B | HOH332 |
Functional Information from PROSITE/UniProt
| site_id | PS00675 |
| Number of Residues | 14 |
| Details | SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLIiGDSGVGKssL |
| Chain | Residue | Details |
| B | LEU11-LEU24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IF3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IF3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IF3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30905672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IF2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-(2-cholinephosphoryl)serine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22307087","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-AMP-tyrosine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
