6IBL
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80
Replaces: 6H7KEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Thioredoxin 1,Beta-1 adrenergic receptor | polymer | 416 | 46769.1 | 2 | UniProt (P0AA25) UniProt (P07700) Pfam (PF00085) Pfam (PF00001) In PDB | Escherichia coli (strain K12) | Trx-1,Beta-1 adrenoreceptor,Beta-T |
| 2 | C, D | Camelid antibody fragment Nb80 | polymer | 121 | 13042.4 | 2 | Lama glama (llama) | ||
| 3 | A, B | ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide | non-polymer | 344.4 | 2 | Chemie (H98) | |||
| 4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | A, B | HEGA-10 | non-polymer | 379.5 | 8 | Chemie (2CV) | |||
| 6 | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, B: 1001 - 1108 (UniProt: P0AA25)
A, B: 44 - 368 (UniProt: P07700)
| PDB | External Database | Details |
|---|---|---|
| Ser 1032 | Cys 33 | engineered mutation |
| Ser 1035 | Cys 36 | engineered mutation |
| Glu 1109 | - | linker |
| Ala 39 | - | linker |
| Ala 40 | - | linker |
| Ala 41 | - | linker |
| Lys 42 | - | linker |
| Val 43 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Arg 68 | conflict |
| Val 90 | Met 90 | conflict |
| Leu 116 | Cys 116 | conflict |
| - | Arg 243 | deletion |
| - | Cys 244 | deletion |
| - | Glu 245 | deletion |
| - | Gly 246 | deletion |
| - | Arg 247 | deletion |
| - | Phe 248 | deletion |
| - | Tyr 249 | deletion |
| - | Gly 250 | deletion |
| - | Ser 251 | deletion |
| - | Gln 252 | deletion |
| - | Glu 253 | deletion |
| - | Gln 254 | deletion |
| - | Pro 255 | deletion |
| - | Gln 256 | deletion |
| - | Pro 257 | deletion |
| - | Pro 258 | deletion |
| - | Pro 259 | deletion |
| - | Leu 260 | deletion |
| - | Pro 261 | deletion |
| - | Gln 262 | deletion |
| - | His 263 | deletion |
| - | Gln 264 | deletion |
| - | Pro 265 | deletion |
| - | Ile 266 | deletion |
| - | Leu 267 | deletion |
| - | Gly 268 | deletion |
| - | Asn 269 | deletion |
| - | Gly 270 | deletion |
| Lys 284 | Arg 284 | engineered mutation |
| Ala 327 | Phe 327 | engineered mutation |
| Met 338 | Phe 338 | engineered mutation |
| Ala 358 | Cys 358 | engineered mutation |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119622.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3770.7 | |
| All* | Total formula weight | 123393.6 |
