6I44
Allosteric activation of human prekallikrein by apple domain disc rotation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Plasma kallikrein | polymer | 627 | 70152.9 | 1 | UniProt (P03952) Pfam (PF00024) Pfam (PF00089) | Homo sapiens (Human) | Fletcher factor,Kininogenin,Plasma prekallikrein,PKK |
2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
3 | C (A) | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
4 | D (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
5 | E (A) | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL | non-polymer | 354.4 | 1 | Chemie (PE4) | |||
6 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
7 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
9 | I, J (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
10 | K, L, M, N (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
11 | O, P, Q, R, S... (A) | FORMIC ACID | non-polymer | 46.0 | 8 | Chemie (FMT) | |||
12 | AA, BA, W, X, Y... (A) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
13 | CA (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
14 | DA (A) | SERINE | non-polymer | 105.1 | 1 | Chemie (SER) | |||
15 | EA (A) | water | water | 18.0 | 637 | Chemie (HOH) |
Sequence modifications
A: 1 - 619 (UniProt: P03952)
PDB | External Database | Details |
---|---|---|
Arg -7 | - | expression tag |
Ser -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ala 323 | Glu 342 | conflict |
Ala 325 | Lys 344 | conflict |
Gln 377 | Asn 396 | conflict |
Gln 434 | Asn 453 | conflict |
Gln 475 | Asn 494 | conflict |
Ala 507 | Lys 526 | conflict |
Ala 509 | Lys 528 | conflict |
Ala 559 | Ser 578 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 70152.9 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 2230.5 | |
All* | Total formula weight | 72807.8 |