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6I44

Allosteric activation of human prekallikrein by apple domain disc rotation

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Plasma kallikreinpolymer62770152.91UniProt (P03952)
Pfam (PF00024)
Pfam (PF00089)
Homo sapiens (Human)Fletcher factor,Kininogenin,Plasma prekallikrein,PKK
2B
(B)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
3C
(A)
BENZAMIDINEnon-polymer120.21Chemie (BEN)
4D
(A)
(4S)-2-METHYL-2,4-PENTANEDIOLnon-polymer118.21Chemie (MPD)
5E
(A)
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOLnon-polymer354.41Chemie (PE4)
6F
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
7G
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
8H
(A)
SODIUM IONnon-polymer23.01Chemie (NA)
9I, J
(A)
DI(HYDROXYETHYL)ETHERnon-polymer106.12Chemie (PEG)
10K, L, M, N
(A)
GLYCEROLnon-polymer92.14Chemie (GOL)
11O, P, Q, R, S...
(A)
FORMIC ACIDnon-polymer46.08Chemie (FMT)
12AA, BA, W, X, Y...
(A)
ACETATE IONnon-polymer59.06Chemie (ACT)
13CA
(A)
GLYCINEnon-polymer75.11Chemie (GLY)
14DA
(A)
SERINEnon-polymer105.11Chemie (SER)
15EA
(A)
waterwater18.0637Chemie (HOH)
Sequence modifications
A: 1 - 619 (UniProt: P03952)
PDBExternal DatabaseDetails
Arg -7-expression tag
Ser -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
Ala 323Glu 342conflict
Ala 325Lys 344conflict
Gln 377Asn 396conflict
Gln 434Asn 453conflict
Gln 475Asn 494conflict
Ala 507Lys 526conflict
Ala 509Lys 528conflict
Ala 559Ser 578conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight70152.9
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules28
Total formula weight2230.5
All*Total formula weight72807.8
*Water molecules are not included.

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PDB entries from 2024-10-30

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