6I44
Allosteric activation of human prekallikrein by apple domain disc rotation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002542 | biological_process | Factor XII activation |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0031638 | biological_process | zymogen activation |
| A | 0031639 | biological_process | plasminogen activation |
| A | 0042730 | biological_process | fibrinolysis |
| A | 0051919 | biological_process | positive regulation of fibrinolysis |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00495 |
| Number of Residues | 84 |
| Details | APPLE Apple domain. CltqLyenafFrggDVasmytpnaqyCqmrCTfhprClLFsFlpassindmekrfgCfLKdSvtgtlpkvhrtgav.SGhSLkqC |
| Chain | Residue | Details |
| A | CYS2-CYS85 | |
| A | CYS92-CYS175 | |
| A | CYS182-CYS265 | |
| A | CYS273-CYS356 |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU411-CYS416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS415 | |
| A | ASP464 | |
| A | ALA559 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:3521732 |
| Chain | Residue | Details |
| A | ASN108 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3521732 |
| Chain | Residue | Details |
| A | ASN289 | |
| A | GLN377 | |
| A | GLN475 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3521732 |
| Chain | Residue | Details |
| A | GLN434 |
