6HJ2
Crystal structure of hPXR in complex with dabrafenib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor subfamily 1 group I member 2 | polymer | 315 | 36193.8 | 1 | UniProt (O75469) Pfam (PF00104) | Homo sapiens (Human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR |
| 2 | B (A) | Dabrafenib | non-polymer | 519.6 | 1 | Chemie (P06) | |||
| 3 | C (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 4 | D (A) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 130 - 434 (UniProt: O75469)
| PDB | External Database | Details |
|---|---|---|
| Met 119 | - | initiating methionine |
| Lys 120 | - | expression tag |
| Lys 121 | - | expression tag |
| Gly 122 | - | expression tag |
| His 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
| His 128 | - | expression tag |
| Gly 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36193.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 579.7 | |
| All* | Total formula weight | 36773.4 |
