6HIL
X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, D, B, C) | Transcriptional enhancer factor TEF-1 | polymer | 218 | 25223.7 | 4 | UniProt (P28347) Pfam (PF17725) | Homo sapiens (Human) | NTEF-1,Protein GT-IIC,TEA domain family member 1,TEAD-1,Transcription factor 13,TCF-13 |
| 2 | B, D, F, H (L, O, M, N) | Transcriptional coactivator YAP1 | polymer | 41 | 4650.3 | 4 | UniProt (P46937) Pfam (PF15238) | Homo sapiens (Human) | Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog |
| 3 | I, J, K, L (A, D, B, C) | MYRISTIC ACID | non-polymer | 228.4 | 4 | Chemie (MYR) | |||
| 4 | M, N, O, P, Q... (A, L, D, O, B...) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A, D, B, C: 193 - 410 (UniProt: P28347)
| PDB | External Database | Details |
|---|---|---|
| His 406 | Tyr 421 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 119496.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 913.5 | |
| All* | Total formula weight | 120409.7 |
