6HIL
X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue MYR A 501 |
Chain | Residue |
A | ALA208 |
A | VAL293 |
A | LYS321 |
A | MET343 |
A | CYS344 |
A | MET347 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue MYR D 501 |
Chain | Residue |
D | LYS321 |
D | MET343 |
D | CYS344 |
D | LEU367 |
D | PHE370 |
D | ILE372 |
D | PHE224 |
D | VAL293 |
D | THR309 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue MYR B 501 |
Chain | Residue |
B | ALA208 |
B | VAL293 |
B | LYS321 |
B | MET343 |
B | CYS344 |
B | MET347 |
B | LEU367 |
B | PHE392 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue MYR C 501 |
Chain | Residue |
C | ALA208 |
C | VAL293 |
C | LYS321 |
C | MET343 |
C | CYS344 |
C | MET347 |
C | LEU367 |
C | ILE372 |
C | PHE392 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
L | SER61 | |
O | SER61 | |
M | SER61 | |
N | SER61 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
L | THR63 | |
O | THR63 | |
M | THR63 | |
N | THR63 |