6HIL
X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MYR A 501 |
| Chain | Residue |
| A | ALA208 |
| A | VAL293 |
| A | LYS321 |
| A | MET343 |
| A | CYS344 |
| A | MET347 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue MYR D 501 |
| Chain | Residue |
| D | LYS321 |
| D | MET343 |
| D | CYS344 |
| D | LEU367 |
| D | PHE370 |
| D | ILE372 |
| D | PHE224 |
| D | VAL293 |
| D | THR309 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue MYR B 501 |
| Chain | Residue |
| B | ALA208 |
| B | VAL293 |
| B | LYS321 |
| B | MET343 |
| B | CYS344 |
| B | MET347 |
| B | LEU367 |
| B | PHE392 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue MYR C 501 |
| Chain | Residue |
| C | ALA208 |
| C | VAL293 |
| C | LYS321 |
| C | MET343 |
| C | CYS344 |
| C | MET347 |
| C | LEU367 |
| C | ILE372 |
| C | PHE392 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| L | SER61 | |
| O | SER61 | |
| M | SER61 | |
| N | SER61 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| L | THR63 | |
| O | THR63 | |
| M | THR63 | |
| N | THR63 |
