6HIK
X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Transcriptional enhancer factor TEF-3 | polymer | 219 | 25475.7 | 1 | UniProt (Q15561) Pfam (PF17725) In PDB | Homo sapiens (Human) | TEA domain family member 4,TEAD-4,Transcription factor 13-like 1,Transcription factor RTEF-1 |
| 2 | L | Transcriptional coactivator YAP1 | polymer | 41 | 4547.2 | 1 | UniProt (P46937) In PDB | Homo sapiens | Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog |
| 3 | A | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 216 - 434 (UniProt: Q15561)
L: 60 - 99 (UniProt: P46937)
| PDB | External Database | Details |
|---|---|---|
| His 429 | Tyr 386 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ace 59 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30022.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 418.3 | |
| All* | Total formula weight | 30441.2 |
