6HIK
X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue MYR A 501 |
| Chain | Residue |
| A | VAL334 |
| A | CYS367 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | HIS426 |
| A | HOH607 |
| A | HOH655 |
| A | HOH711 |
| A | GLY216 |
| A | HIS249 |
| A | ILE250 |
| A | GLY251 |
| A | GLN252 |
| A | SER253 |
| A | SER254 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | ARG351 |
| A | ARG351 |
| A | SER358 |
| A | ARG360 |
| A | HOH606 |
| A | HOH611 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by LATS1 and LATS2","evidences":[{"source":"PubMed","id":"17974916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18158288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
