6HEI

Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28	polymer	382	44586.7	1	UniProt (Q96RU2) Pfam (PF00443)	Homo sapiens (Human)	Deubiquitinating enzyme 28,Ubiquitin thioesterase 28,Ubiquitin-specific-processing protease 28,Deubiquitinating enzyme 28,Ubiquitin thioesterase 28,Ubiquitin-specific-processing protease 28
2	B (B)	Polyubiquitin-B	polymer	78	8713.0	1	UniProt (P0CG47) Pfam (PF00240)	Homo sapiens (Human)
3	C (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	D, E (A, B)	water	water		18.0	276	Chemie (HOH)

Sequence modifications

A: 149 - 399 (UniProt: Q96RU2)

PDB	External Database	Details
Gly 148	-	expression tag

A: 580 - 703 (UniProt: Q96RU2)

PDB	External Database	Details
Gly 400	-	linker
Ser 401	-	linker
Gly 402	-	linker
Ser 403	-	linker
Gly 404	-	linker
Ser 405	-	linker

B: 1 - 75 (UniProt: P0CG47)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag
Aye 76	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53299.7
Non-Polymers*	Number of molecules	1
	Total formula weight	62.1
All*	Total formula weight	53361.8

*Water molecules are not included.