6HAY

Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Probable global transcription activator SNF2L2	polymer	123	14380.5	2	UniProt (P51531) Pfam (PF00439) In PDB	Homo sapiens (Human)	ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
2	B, F	von Hippel-Lindau disease tumor suppressor	polymer	162	18702.3	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (Human)	Protein G7,pVHL
3	C, G	Elongin-C	polymer	97	10974.6	2	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4	D, H	Elongin-B	polymer	104	11748.4	2	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
5	B, F	(2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		918.1	2	Chemie (FX8)
6	G, H, B, C, D...	1,2-ETHANEDIOL	non-polymer		62.1	22	Chemie (EDO)
7	B	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
8	F	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
9		water	water		18.0	300	Chemie (HOH)

Sequence modifications

A, E: 1373 - 1493 (UniProt: P51531)

PDB	External Database	Details
Ser 1371	-	expression tag
Met 1372	-	expression tag

B, F: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

C, G: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	111611.7
Non-Polymers*	Number of molecules	26
	Total formula weight	3486.0
All*	Total formula weight	115097.7

*Water molecules are not included.