6HAY

Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030891	cellular_component	VCB complex
D	0070449	cellular_component	elongin complex
E	0006338	biological_process	chromatin remodeling
E	0016586	cellular_component	RSC-type complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0030891	cellular_component	VCB complex
H	0070449	cellular_component	elongin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue FX8 B 301

Chain	Residue
A	VAL1408
B	ARG69
B	TRP88
B	PHE91
B	TYR98
B	PRO99
B	ARG107
B	ILE109
B	HIS110
B	SER111
B	TYR112
A	PHE1409
B	HIS115
B	TRP117
B	EDO304
B	HOH429
A	LEU1418
A	TYR1421
A	VAL1429
A	ALA1460
A	PHE1463
A	ASN1464
A	ILE1470

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO B 302

Chain	Residue
B	ARG161
B	HOH404
B	HOH421
C	GLU92

---

site_id	AC3
Number of Residues	1
Details	binding site for residue EDO B 303

Chain	Residue
B	GLY123

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO B 304

Chain	Residue
A	GLN1469
B	ARG108
B	ILE109
B	HIS110
B	FX8301

---

site_id	AC5
Number of Residues	3
Details	binding site for residue FMT B 305

Chain	Residue
B	ARG210
H	ASP48
H	ILE90

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO C 201

Chain	Residue
C	HIS68
C	SER71
C	MET75
C	ILE99
C	HOH320
D	PHE93

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO C 202

Chain	Residue
C	SER87
F	ARG107
F	ARG108

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO C 203

Chain	Residue
C	ARG63
C	GLU64
C	ILE65
C	PHE109

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO D 201

Chain	Residue
D	ASP40
D	GLU41
D	ARG80
D	ALA81
D	ASP82

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO D 202

Chain	Residue
D	ASP48
D	LEU88

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO D 203

Chain	Residue
D	LEU88
D	CYS89
D	ILE90

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO D 204

Chain	Residue
D	ASP47
D	THR74

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO D 205

Chain	Residue
D	THR23
D	PHE25
D	GLU26
D	ASP53
D	GLY54
D	HOH303
F	ARG176
F	TYR185

---

site_id	AD5
Number of Residues	26
Details	binding site for residue FX8 F 301

Chain	Residue
E	VAL1408
E	PHE1409
E	LEU1412
E	TYR1421
E	VAL1429
E	ALA1460
E	PHE1463
E	ASN1464
E	ILE1470
E	HOH1506
F	ARG69
F	TRP88
F	PHE91
F	TYR98
F	PRO99
F	ARG107
F	ILE109
F	HIS110
F	SER111
F	TYR112
F	HIS115
F	TRP117
F	EDO304
F	EDO305
F	HOH425
F	HOH438

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO F 302

Chain	Residue
G	GLU92
F	PRO81
F	HOH401
F	HOH415
F	HOH449

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO F 303

Chain	Residue
F	THR124
F	ASP126
F	GLN164
F	ARG167
F	PRO192
F	HOH410

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO F 304

Chain	Residue
E	GLN1469
F	ILE109
F	HIS110
F	FX8301
F	EDO305

---

site_id	AD9
Number of Residues	9
Details	binding site for residue EDO F 305

Chain	Residue
E	SER1468
E	GLN1469
E	ILE1470
E	HOH1506
F	HIS110
F	TYR112
F	FX8301
F	EDO304
F	HOH433

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EPE F 306

Chain	Residue
F	ASP179
F	ILE180
F	VAL181
F	ARG182

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO G 201

Chain	Residue
G	GLU64
G	ILE65
G	GLU102
G	MET105

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO G 202

Chain	Residue
F	SER80
F	PRO81
G	GLU89
G	ILE90

---

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO G 203

Chain	Residue
B	ARG108
G	SER86
G	SER87

---

site_id	AE5
Number of Residues	6
Details	binding site for residue EDO H 201

Chain	Residue
E	GLU1466
F	PRO71
H	ASP48
H	GLN49
H	LEU50
H	EDO204

---

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO H 202

Chain	Residue
H	LYS46
H	ASP47
H	ALA73
H	THR74
H	HOH309

---

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO H 203

Chain	Residue
H	MET6
H	PHE93
H	HOH304
H	HOH307
H	HOH309

---

site_id	AE8
Number of Residues	2
Details	binding site for residue EDO H 204

Chain	Residue
H	EDO201
H	HOH323

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF

Chain	Residue	Details
A	SER1406-PHE1463

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
D	MET1
H	MET1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
D	THR84
H	THR84

---