6GYR
Transcription factor dimerization activates the p300 acetyltransferase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone acetyltransferase p300 | polymer | 588 | 68652.2 | 4 | UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF23570) Pfam (PF08214) | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300 |
| 2 | E, F, G, I, J... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 14 | Chemie (ZN) | |||
| 3 | H, M, R, V (A, B, C, D) | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | non-polymer | 994.8 | 4 | Chemie (01K) |
Sequence modifications
A, B, C, D: 1046 - 1664 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Ala 1045 | - | expression tag |
| Phe 1467 | Tyr 1467 | engineered mutation |
| - | Ser 1534 | deletion |
| - | Asn 1535 | deletion |
| - | Glu 1536 | deletion |
| - | Ser 1537 | deletion |
| - | Thr 1538 | deletion |
| - | Asp 1539 | deletion |
| - | Val 1540 | deletion |
| - | Thr 1541 | deletion |
| - | Lys 1542 | deletion |
| - | Gly 1543 | deletion |
| - | Asp 1544 | deletion |
| - | Ser 1545 | deletion |
| - | Lys 1546 | deletion |
| - | Asn 1547 | deletion |
| - | Ala 1548 | deletion |
| - | Lys 1549 | deletion |
| - | Lys 1550 | deletion |
| - | Lys 1551 | deletion |
| - | Asn 1552 | deletion |
| - | Asn 1553 | deletion |
| - | Lys 1554 | deletion |
| - | Lys 1555 | deletion |
| - | Thr 1556 | deletion |
| - | Ser 1557 | deletion |
| - | Lys 1558 | deletion |
| - | Asn 1559 | deletion |
| - | Lys 1560 | deletion |
| - | Ser 1561 | deletion |
| - | Ser 1562 | deletion |
| - | Leu 1563 | deletion |
| - | Ser 1564 | deletion |
| - | Arg 1565 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 274609.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 4894.9 | |
| All* | Total formula weight | 279503.9 |
