6GYR

Transcription factor dimerization activates the p300 acetyltransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Histone acetyltransferase p300	polymer	588	68652.2	4	UniProt (Q09472) Pfam (PF00439) Pfam (PF06001) Pfam (PF08214) In PDB	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
2	A, B, C, D	ZINC ION	non-polymer		65.4	14	Chemie (ZN)
3	A, B, C, D	[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate	non-polymer		994.8	4	Chemie (01K)

Sequence modifications

A, B, C, D: 1046 - 1664 (UniProt: Q09472)

PDB	External Database	Details
Ala 1045	-	expression tag
Phe 1467	Tyr 1467	engineered mutation
-	Ser 1534	deletion
-	Asn 1535	deletion
-	Glu 1536	deletion
-	Ser 1537	deletion
-	Thr 1538	deletion
-	Asp 1539	deletion
-	Val 1540	deletion
-	Thr 1541	deletion
-	Lys 1542	deletion
-	Gly 1543	deletion
-	Asp 1544	deletion
-	Ser 1545	deletion
-	Lys 1546	deletion
-	Asn 1547	deletion
-	Ala 1548	deletion
-	Lys 1549	deletion
-	Lys 1550	deletion
-	Lys 1551	deletion
-	Asn 1552	deletion
-	Asn 1553	deletion
-	Lys 1554	deletion
-	Lys 1555	deletion
-	Thr 1556	deletion
-	Ser 1557	deletion
-	Lys 1558	deletion
-	Asn 1559	deletion
-	Lys 1560	deletion
-	Ser 1561	deletion
-	Ser 1562	deletion
-	Leu 1563	deletion
-	Ser 1564	deletion
-	Arg 1565	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	274609.0
Non-Polymers*	Number of molecules	18
	Total formula weight	4894.9
All*	Total formula weight	279503.9

*Water molecules are not included.