6GYR

Transcription factor dimerization activates the p300 acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0004402	molecular_function	histone acetyltransferase activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0004402	molecular_function	histone acetyltransferase activity
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1701

Chain	Residue
A	CYS1163
A	CYS1164
A	HIS1255
A	CYS1258

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1702

Chain	Residue
A	CYS1247
A	CYS1250
A	CYS1272
A	CYS1275

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1703

Chain	Residue
A	CYS1183
A	CYS1201
A	CYS1204
A	CYS1177

---

site_id	AC4
Number of Residues	17
Details	binding site for residue 01K A 1704

Chain	Residue
A	SER1396
A	TYR1397
A	LEU1398
A	ASP1399
A	SER1400
A	ARG1410
A	THR1411
A	TYR1414
A	TRP1436
A	CYS1438
A	PRO1440
A	TYR1446
A	LYS1456
A	ILE1457
A	PRO1458
A	ARG1462
A	TRP1466

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 1705

Chain	Residue
A	HIS1315
A	CYS1408
C	HIS1315
C	CYS1408

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 1701

Chain	Residue
B	CYS1163
B	CYS1164
B	HIS1255
B	CYS1258

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 1702

Chain	Residue
B	CYS1247
B	CYS1250
B	CYS1272
B	CYS1275

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN B 1703

Chain	Residue
B	CYS1177
B	GLY1179
B	CYS1183
B	CYS1201
B	CYS1204

---

site_id	AC9
Number of Residues	19
Details	binding site for residue 01K B 1704

Chain	Residue
B	SER1396
B	TYR1397
B	LEU1398
B	ASP1399
B	SER1400
B	ARG1410
B	THR1411
B	TYR1414
B	TRP1436
B	CYS1438
B	PRO1440
B	ASP1444
B	TYR1446
B	LYS1456
B	ILE1457
B	PRO1458
B	ARG1462
B	TRP1466
D	LYS1407

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1705

Chain	Residue
B	HIS1315
B	CYS1408
D	HIS1315
D	CYS1408

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 1701

Chain	Residue
C	CYS1163
C	CYS1164
C	HIS1255
C	CYS1258

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 1702

Chain	Residue
C	CYS1247
C	CYS1250
C	CYS1272
C	CYS1275

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN C 1703

Chain	Residue
C	CYS1177
C	CYS1183
C	CYS1201
C	CYS1204

---

site_id	AD5
Number of Residues	20
Details	binding site for residue 01K C 1704

Chain	Residue
C	PHE1467
C	ARG1627
C	SER1396
C	TYR1397
C	LEU1398
C	ASP1399
C	SER1400
C	LYS1407
C	ARG1410
C	THR1411
C	TYR1414
C	TRP1436
C	PRO1440
C	TYR1446
C	LYS1456
C	ILE1457
C	PRO1458
C	ARG1462
C	LEU1463
C	TRP1466

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN D 1701

Chain	Residue
D	CYS1163
D	CYS1164
D	HIS1255
D	CYS1258

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN D 1702

Chain	Residue
D	CYS1247
D	CYS1250
D	CYS1272
D	CYS1275

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 1703

Chain	Residue
D	CYS1177
D	CYS1183
D	CYS1201
D	CYS1204

---

site_id	AD9
Number of Residues	24
Details	binding site for residue 01K D 1704

Chain	Residue
B	LYS1407
D	SER1396
D	TYR1397
D	LEU1398
D	ASP1399
D	SER1400
D	ARG1410
D	THR1411
D	TYR1414
D	TRP1436
D	ALA1437
D	CYS1438
D	PRO1439
D	PRO1440
D	ASP1444
D	TYR1446
D	GLN1455
D	LYS1456
D	ILE1457
D	PRO1458
D	LYS1459
D	ARG1462
D	TRP1466
D	ARG1627

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY

Chain	Residue	Details
A	SER1072-TYR1131

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	428
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"18273021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24819397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"B2RWS6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17065153","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"15004546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---