Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GYR

Transcription factor dimerization activates the p300 acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0004402	molecular_function	histone acetyltransferase activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0004402	molecular_function	histone acetyltransferase activity
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1701

Chain	Residue
A	CYS1163
A	CYS1164
A	HIS1255
A	CYS1258

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1702

Chain	Residue
A	CYS1247
A	CYS1250
A	CYS1272
A	CYS1275

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1703

Chain	Residue
A	CYS1183
A	CYS1201
A	CYS1204
A	CYS1177

site_id	AC4
Number of Residues	17
Details	binding site for residue 01K A 1704

Chain	Residue
A	SER1396
A	TYR1397
A	LEU1398
A	ASP1399
A	SER1400
A	ARG1410
A	THR1411
A	TYR1414
A	TRP1436
A	CYS1438
A	PRO1440
A	TYR1446
A	LYS1456
A	ILE1457
A	PRO1458
A	ARG1462
A	TRP1466

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 1705

Chain	Residue
A	HIS1315
A	CYS1408
C	HIS1315
C	CYS1408

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 1701

Chain	Residue
B	CYS1163
B	CYS1164
B	HIS1255
B	CYS1258

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 1702

Chain	Residue
B	CYS1247
B	CYS1250
B	CYS1272
B	CYS1275

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN B 1703

Chain	Residue
B	CYS1177
B	GLY1179
B	CYS1183
B	CYS1201
B	CYS1204

site_id	AC9
Number of Residues	19
Details	binding site for residue 01K B 1704

Chain	Residue
B	SER1396
B	TYR1397
B	LEU1398
B	ASP1399
B	SER1400
B	ARG1410
B	THR1411
B	TYR1414
B	TRP1436
B	CYS1438
B	PRO1440
B	ASP1444
B	TYR1446
B	LYS1456
B	ILE1457
B	PRO1458
B	ARG1462
B	TRP1466
D	LYS1407

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1705

Chain	Residue
B	HIS1315
B	CYS1408
D	HIS1315
D	CYS1408

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 1701

Chain	Residue
C	CYS1163
C	CYS1164
C	HIS1255
C	CYS1258

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 1702

Chain	Residue
C	CYS1247
C	CYS1250
C	CYS1272
C	CYS1275

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN C 1703

Chain	Residue
C	CYS1177
C	CYS1183
C	CYS1201
C	CYS1204

site_id	AD5
Number of Residues	20
Details	binding site for residue 01K C 1704

Chain	Residue
C	PHE1467
C	ARG1627
C	SER1396
C	TYR1397
C	LEU1398
C	ASP1399
C	SER1400
C	LYS1407
C	ARG1410
C	THR1411
C	TYR1414
C	TRP1436
C	PRO1440
C	TYR1446
C	LYS1456
C	ILE1457
C	PRO1458
C	ARG1462
C	LEU1463
C	TRP1466

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN D 1701

Chain	Residue
D	CYS1163
D	CYS1164
D	HIS1255
D	CYS1258

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN D 1702

Chain	Residue
D	CYS1247
D	CYS1250
D	CYS1272
D	CYS1275

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 1703

Chain	Residue
D	CYS1177
D	CYS1183
D	CYS1201
D	CYS1204

site_id	AD9
Number of Residues	24
Details	binding site for residue 01K D 1704

Chain	Residue
B	LYS1407
D	SER1396
D	TYR1397
D	LEU1398
D	ASP1399
D	SER1400
D	ARG1410
D	THR1411
D	TYR1414
D	TRP1436
D	ALA1437
D	CYS1438
D	PRO1439
D	PRO1440
D	ASP1444
D	TYR1446
D	GLN1455
D	LYS1456
D	ILE1457
D	PRO1458
D	LYS1459
D	ARG1462
D	TRP1466
D	ARG1627

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY

Chain	Residue	Details
A	SER1072-TYR1131

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:24819397

Chain	Residue	Details
A	LEU1398
B	TRP1466
C	LEU1398
C	ARG1410
C	ILE1457
C	ARG1462
C	TRP1466
D	LEU1398
D	ARG1410
D	ILE1457
D	ARG1462
A	ARG1410
D	TRP1466
A	ILE1457
A	ARG1462
A	TRP1466
B	LEU1398
B	ARG1410
B	ILE1457
B	ARG1462

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:B2RWS6

Chain	Residue	Details
A	LYS1180
B	LYS1180
C	LYS1180
D	LYS1180

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:17065153

Chain	Residue	Details
A	LYS1336
A	LYS1473
B	LYS1336
B	LYS1473
C	LYS1336
C	LYS1473
D	LYS1336
D	LYS1473

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269\|PubMed:15004546

Chain	Residue	Details
A	LYS1499
B	LYS1499
C	LYS1499
D	LYS1499

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18995842, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	PRO1574
A	ASN1578
B	PRO1574
B	ASN1578
C	PRO1574
C	ASN1578
D	PRO1574
D	ASN1578

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269\|PubMed:15004546, ECO:0000269\|PubMed:18995842

Chain	Residue	Details
A	SER1581
B	SER1581
C	SER1581
D	SER1581

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269\|PubMed:15004546, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	ALA1586
A	LYS1592
B	ALA1586
B	LYS1592
C	ALA1586
C	LYS1592
D	ALA1586
D	LYS1592

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	THR1587
A	PRO1615
B	THR1587
B	PRO1615
C	THR1587
C	PRO1615
D	THR1587
D	PRO1615

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:15004546, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS1590
B	LYS1590
C	LYS1590
D	LYS1590

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)