6GMR
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (C) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (H) | Hypoxia inducible factor 1alpha, residues 559-577 | polymer | 19 | 2260.5 | 1 | Pfam (PF11413) UniProt (by SIFTS) (Q16665) | Homo sapiens | |
| 4 | D (V) | von Hippel-Lindau disease tumor suppressor | polymer | 163 | 18840.4 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 5 | E (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (V) | (4-pyrrol-1-ylphenyl)methanol | non-polymer | 173.2 | 1 | Chemie (F4K) | |||
| 7 | G (V) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | H, I, J, K (B, C, H, V) | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
C: 17 - 112 (UniProt: Q15369)
V: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | expression tag |
| Ser 52 | - | expression tag |
| His 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 45223.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 361.4 | |
| All* | Total formula weight | 45584.7 |
