6GMR
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001222 | molecular_function | transcription corepressor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030891 | cellular_component | VCB complex |
| B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
| B | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| B | 0065003 | biological_process | protein-containing complex assembly |
| B | 0070449 | cellular_component | elongin complex |
| B | 0140958 | biological_process | target-directed miRNA degradation |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | MET1 |
| B | ASP2 |
| B | PHE4 |
| B | ARG68 |
| C | ARG82 |
| V | GLN132 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue F4K V 301 |
| Chain | Residue |
| V | GLU134 |
| V | TYR156 |
| V | GLU160 |
| V | ASP197 |
| V | HOH442 |
| V | ARG120 |
| V | GLY127 |
| V | LEU128 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL V 302 |
| Chain | Residue |
| V | ARG161 |
| V | GLN164 |
| V | HOH419 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097 |
| Chain | Residue | Details |
| H | HYP564 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:20889502 |
| Chain | Residue | Details |
| H | SER576 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869 |
| Chain | Residue | Details |
| B | SER108 | |
| B | SER111 |
