6GMQ

pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Elongin-B	polymer	104	11956.4	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E (B, E)	Elongin-C	polymer	97	11078.6	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, I, L (C, F, I, L)	von Hippel-Lindau disease tumor suppressor	polymer	162	18806.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (Human)	Protein G7,pVHL
4	H, K (H, K)	Elongin-C	polymer	97	10974.6	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
5	M, N, R (F, I, L)	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
6	O, Q (I, L)	(4-pyrrol-1-ylphenyl)methanol	non-polymer		173.2	2	Chemie (F4K)
7	P, S (I, L)	ISOPROPYL ALCOHOL	non-polymer		60.1	2	Chemie (IPA)
8	AA, BA, CA, DA, EA... (H, I, J, K, L...)	water	water		18.0	212	Chemie (HOH)

Sequence modifications

B, E: 17 - 111 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine
Cas 112	-	expression tag

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	167157.0
Non-Polymers*	Number of molecules	7
	Total formula weight	643.7
All*	Total formula weight	167800.8

*Water molecules are not included.