6GMQ
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| A | 0030891 | cellular_component | VCB complex |
| A | 0070449 | cellular_component | elongin complex |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| D | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| D | 0030891 | cellular_component | VCB complex |
| D | 0070449 | cellular_component | elongin complex |
| E | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| G | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| G | 0030891 | cellular_component | VCB complex |
| G | 0070449 | cellular_component | elongin complex |
| H | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| J | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| J | 0030891 | cellular_component | VCB complex |
| J | 0070449 | cellular_component | elongin complex |
| K | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue ACT F 301 |
| Chain | Residue |
| F | ARG161 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue ACT I 301 |
| Chain | Residue |
| I | ARG161 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue F4K I 302 |
| Chain | Residue |
| I | LEU118 |
| I | ARG120 |
| I | LEU128 |
| I | LEU129 |
| I | GLU134 |
| I | TYR156 |
| I | ASP197 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue IPA I 303 |
| Chain | Residue |
| I | TYR98 |
| I | SER111 |
| I | TYR112 |
| I | HIS115 |
| I | TRP117 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue F4K L 301 |
| Chain | Residue |
| L | LEU118 |
| L | ARG120 |
| L | GLY127 |
| L | LEU128 |
| L | TYR156 |
| L | ASP197 |
| L | ARG200 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue ACT L 302 |
| Chain | Residue |
| L | ARG161 |
| L | HOH414 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue IPA L 303 |
| Chain | Residue |
| L | TRP88 |
| L | HIS110 |
| L | SER111 |
| L | HIS115 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide ASP E 111 and CAS E 112 |
| Chain | Residue |
| E | SER39 |
| E | VAL73 |
| E | PHE77 |
| E | ALA107 |
| E | ASN108 |
| E | PHE109 |
| E | LEU110 |
| F | THR157 |
| F | LEU158 |
| F | LYS159 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Region: {"description":"Interaction with Elongin BC complex"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 165 |
| Details | Region: {"description":"Involved in binding to CCT complex"} |
| Chain | Residue | Details |
