6GKU

Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Galectin-10	polymer	180	20685.2	1	UniProt (Q05315) Pfam (PF00337)	Homo sapiens (Human)	Gal-10,Charcot-Leyden crystal protein,CLC,Eosinophil lysophospholipase,Lysolecithin acylhydrolase
2	B (H)	Fab 6F5 - Heavy Chain	polymer	228	24206.0	1		Lama glama (llama)
3	C (L)	Fab 6F5 - Light chain	polymer	216	22872.3	1		Lama glama (llama)
4	D (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	E (L)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	F, G, H (A, H, L)	water	water		18.0	823	Chemie (HOH)

Sequence modifications

A: 1 - 142 (UniProt: Q05315)

PDB	External Database	Details
Met -37	-	initiating methionine
Ala -36	-	expression tag
Ser -35	-	expression tag
Thr -34	-	expression tag
Thr -33	-	expression tag
His -32	-	expression tag
His -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
Asp -26	-	expression tag
Thr -25	-	expression tag
Asp -24	-	expression tag
Ile -23	-	expression tag
Pro -22	-	expression tag
Thr -21	-	expression tag
Thr -20	-	expression tag
Gly -19	-	expression tag
Gly -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
Arg -15	-	expression tag
Pro -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Lys -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	67763.6
Non-Polymers*	Number of molecules	2
	Total formula weight	190.3
All*	Total formula weight	67953.8

*Water molecules are not included.