6GJK

A degradation product of PD 404182 (P2742) bound to Histone Deacetylase-like Amidohydrolase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone deacetylase-like amidohydrolase	polymer	375	40253.5	2	UniProt (Q70I53)	Alcaligenaceae bacterium FB188	HDAH
2	C, M (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, E, N, O (A, B)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
4	F, P (A, B)	PENTAETHYLENE GLYCOL	non-polymer		238.3	2	Chemie (1PE)
5	G, H, Q, R, S... (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	6	Chemie (PEG)
6	I, J, U, V (A, B)	2-(1,4,5,6-tetrahydropyrimidin-2-yl)benzenethiol	non-polymer		192.3	4	Chemie (F0Z)
7	K, W (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
8	L (A)	D-MALATE	non-polymer		134.1	1	Chemie (MLT)
9	X, Y (A, B)	water	water		18.0	830	Chemie (HOH)

Sequence modifications

A, B: 2 - 369 (UniProt: Q70I53)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Pro 251	His 251	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80507.0
Non-Polymers*	Number of molecules	21
	Total formula weight	2421.8
All*	Total formula weight	82928.7

*Water molecules are not included.