Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | ACT409 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 402 |
| Chain | Residue |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| A | LEU202 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue K A 403 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | THR199 |
| A | TYR226 |
| A | HOH607 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE A 404 |
| Chain | Residue |
| A | ARG173 |
| A | PRO195 |
| A | TYR226 |
| A | HOH835 |
| A | HOH849 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 405 |
| Chain | Residue |
| A | ARG355 |
| A | HOH852 |
| B | THR349 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 406 |
| Chain | Residue |
| A | ASN185 |
| A | GLN188 |
| A | ASP189 |
| A | TRP192 |
| A | HOH553 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue F0Z A 407 |
| Chain | Residue |
| A | CYS51 |
| A | ILE56 |
| A | GLU57 |
| A | MLT410 |
| A | HOH752 |
| B | THR9 |
| B | PEG406 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue F0Z A 408 |
| Chain | Residue |
| A | ARG254 |
| A | CYS295 |
| A | ASP298 |
| A | ILE299 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue ACT A 409 |
| Chain | Residue |
| A | HIS142 |
| A | HIS143 |
| A | GLY151 |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | GLY310 |
| A | TYR312 |
| A | ZN401 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue MLT A 410 |
| Chain | Residue |
| A | HIS47 |
| A | F0Z407 |
| A | HOH522 |
| A | HOH548 |
| A | HOH667 |
| A | HOH713 |
| B | HIS47 |
| B | F0Z409 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | ACT411 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue K B 402 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue K B 403 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | THR199 |
| B | TYR226 |
| B | HOH626 |
| B | HOH646 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE B 404 |
| Chain | Residue |
| B | GLU172 |
| B | ARG173 |
| B | PRO195 |
| B | ASN222 |
| B | HOH505 |
| B | HOH667 |
| B | HOH739 |
| B | HOH796 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 405 |
| Chain | Residue |
| B | ARG355 |
| B | HOH673 |
| B | HOH680 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 406 |
| Chain | Residue |
| A | F0Z407 |
| A | HOH667 |
| B | TRP7 |
| B | PRO61 |
| B | ILE62 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 407 |
| Chain | Residue |
| B | GLN188 |
| B | TRP192 |
| B | ASP211 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 408 |
| Chain | Residue |
| B | ARG74 |
| B | HIS146 |
| B | ASP189 |
| B | ILE190 |
| B | HOH536 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue ACT B 411 |
| Chain | Residue |
| B | GLY151 |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | GLY310 |
| B | TYR312 |
| B | ZN401 |
| B | HIS142 |
| B | HIS143 |
| site_id | AE2 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide F0Z B 409 and CYS B 51 |
| Chain | Residue |
| A | TRP7 |
| A | THR9 |
| A | MLT410 |
| B | HIS47 |
| B | GLU48 |
| B | LEU49 |
| B | VAL50 |
| B | ALA52 |
| B | SER53 |
| B | GLY54 |
| B | ILE56 |
| B | GLU57 |
| B | HOH577 |
| B | HOH734 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide F0Z B 410 and CYS B 295 |
| Chain | Residue |
| B | LEU250 |
| B | ARG254 |
| B | ARG291 |
| B | THR292 |
| B | ILE293 |
| B | ASP294 |
| B | ALA296 |
| B | ALA297 |
| B | ASP298 |
| B | ILE299 |
| B | HOH530 |
| B | HOH595 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
