6G79
Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 2 | B (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 3 | C (A) | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 225 | 25155.7 | 1 | UniProt (P09471) UniProt (A0A0P7W0C8) Pfam (PF00503) | Homo sapiens (Human) | |
| 4 | D (S) | 5-hydroxytryptamine receptor 1B | polymer | 364 | 41273.4 | 1 | UniProt (P28222) Pfam (PF00001) | Homo sapiens (Human) | 5-HT1B,S12,Serotonin 1D beta receptor,5-HT-1D-beta,Serotonin receptor 1B |
| 5 | E (S) | 2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium | non-polymer | 404.5 | 1 | Chemie (EP5) |
Sequence modifications
G: 1 - 71 (UniProt: P59768)
A: 4 - 173 (UniProt: P09471)
A: 182 - 354 (UniProt: A0A0P7W0C8)
S: 34 - 390 (UniProt: P28222)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 42 | Gly 42 | conflict |
| Asn 43 | Glu 43 | conflict |
| Gly 174 | - | linker |
| Gly 175 | - | linker |
| Ser 176 | - | linker |
| Gly 177 | - | linker |
| Gly 178 | - | linker |
| Ser 179 | - | linker |
| Gly 180 | - | linker |
| Gly 181 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 227 | Ala 260 | conflict |
| - | Gly 263 | deletion |
| - | Tyr 264 | deletion |
| Tyr 231 | Gln 266 | conflict |
| Gly 276 | Ala 301 | conflict |
| Pro 283 | Ala 308 | conflict |
| Thr 285 | Ser 310 | conflict |
| Asn 330 | Gly 355 | conflict |
| Ala 332 | Ile 357 | conflict |
| Ile 335 | Val 360 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Trp 138 | Leu 138 | conflict |
| Glu 391 | - | expression tag |
| Asn 392 | - | expression tag |
| Leu 393 | - | expression tag |
| Tyr 394 | - | expression tag |
| Phe 395 | - | expression tag |
| Gln 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111559.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 404.5 | |
| All* | Total formula weight | 111964.4 |
