Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6G79

Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
S0002031biological_processG protein-coupled receptor internalization
S0004930molecular_functionG protein-coupled receptor activity
S0004993molecular_functionG protein-coupled serotonin receptor activity
S0005515molecular_functionprotein binding
S0005737cellular_componentcytoplasm
S0005783cellular_componentendoplasmic reticulum
S0005886cellular_componentplasma membrane
S0007186biological_processG protein-coupled receptor signaling pathway
S0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
S0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
S0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
S0007205biological_processprotein kinase C-activating G protein-coupled receptor signaling pathway
S0007268biological_processchemical synaptic transmission
S0007631biological_processfeeding behavior
S0014053biological_processnegative regulation of gamma-aminobutyric acid secretion
S0014059biological_processregulation of dopamine secretion
S0014063biological_processnegative regulation of serotonin secretion
S0016020cellular_componentmembrane
S0030425cellular_componentdendrite
S0030594molecular_functionneurotransmitter receptor activity
S0032229biological_processnegative regulation of synaptic transmission, GABAergic
S0042220biological_processresponse to cocaine
S0042310biological_processvasoconstriction
S0042734cellular_componentpresynaptic membrane
S0042756biological_processdrinking behavior
S0044305cellular_componentcalyx of Held
S0045471biological_processresponse to ethanol
S0046849biological_processbone remodeling
S0050795biological_processregulation of behavior
S0051378molecular_functionserotonin binding
S0051385biological_processresponse to mineralocorticoid
S0051967biological_processnegative regulation of synaptic transmission, glutamatergic
S0071312biological_processcellular response to alkaloid
S0071466biological_processcellular response to xenobiotic stimulus
S0071502biological_processcellular response to temperature stimulus
S0098666cellular_componentG protein-coupled serotonin receptor complex
S0099154cellular_componentserotonergic synapse
S0099171biological_processpresynaptic modulation of chemical synaptic transmission
S0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
S0099626molecular_functionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
S1901363molecular_functionheterocyclic compound binding
S1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
S2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue EP5 S 401
ChainResidue
SASP129
SPHE331
SSER334
SMET337
SPHE351
SILE130
SCYS133
STHR134
SVAL201
STHR203
SSER212
STRP327
SPHE330

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCVIALDRYWaI
ChainResidueDetails
SALA135-ILE151

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
SVAL50-TYR75
ASER47
ATHR182
AASP201
ALYS280
APHE336

site_idSWS_FT_FI2
Number of Residues131
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
SARG76-ALA84
SASP146-ARG165
SGLY229-THR315
SSER372-SER390

site_idSWS_FT_FI3
Number of Residues25
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
SASN85-THR110

site_idSWS_FT_FI4
Number of Residues41
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
SVAL111-ASP123
SARG188-HIS205
SMET337-ALA349

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
SPHE124-LEU145

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
SALA166-TRP187

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
SILE206-TYR228

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
SLEU316-VAL336

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
SILE350-MET371

site_idSWS_FT_FI10
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:23519210, ECO:0007744|PDB:4IAR
ChainResidueDetails
SASP129
STHR134
SVAL201

site_idSWS_FT_FI11
Number of Residues1
DetailsSITE: Important for species-specific agonist sensitivity
ChainResidueDetails
STHR355

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
SCYS388

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon