6G4G

Full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) including the SMB domains but with a partially disordered active site structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	polymer	840	95575.8	4	UniProt (P97675) Pfam (PF01033) Pfam (PF01663) In PDB	Rattus norvegicus (Rat)	E-NPP 3,B10,Phosphodiesterase I beta,PD-Ibeta,Phosphodiesterase I/nucleotide pyrophosphatase 3,RB13-6 antigen
2	E, F, G, H, I...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	7	In PDB GlyTouCan (G42666HT)
3	A, B, C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)

Sequence modifications

A, B, C, D: 49 - 875 (UniProt: P97675)

PDB	External Database	Details
Ala 45	-	expression tag
Glu 46	-	expression tag
Thr 47	-	expression tag
Gly 48	-	expression tag
Val 201	Met 201	variant
Asn 596	Ser 596	variant
Arg 597	Gly 597	variant
Gly 876	-	expression tag
Thr 877	-	expression tag
Lys 878	-	expression tag
His 879	-	expression tag
His 880	-	expression tag
His 881	-	expression tag
His 882	-	expression tag
His 883	-	expression tag
His 884	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	382303.2
Branched	Number of molecules	7
	Total formula weight	2970.8
Non-Polymers*	Number of molecules	12
	Total formula weight	1930.0
All*	Total formula weight	387204.0

*Water molecules are not included.