Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6G4G

Full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) including the SMB domains but with a partially disordered active site structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002276	biological_process	basophil activation involved in immune response
A	0003676	molecular_function	nucleic acid binding
A	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A	0004528	molecular_function	phosphodiesterase I activity
A	0004551	molecular_function	dinucleotide phosphatase activity
A	0005509	molecular_function	calcium ion binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009143	biological_process	nucleoside triphosphate catabolic process
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0016324	cellular_component	apical plasma membrane
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0030505	biological_process	inorganic diphosphate transport
A	0033007	biological_process	negative regulation of mast cell activation involved in immune response
A	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
A	0036219	molecular_function	GTP diphosphatase activity
A	0036221	molecular_function	UTP diphosphatase activity
A	0046034	biological_process	ATP metabolic process
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0047693	molecular_function	ATP diphosphatase activity
A	0047710	molecular_function	bis(5'-adenosyl)-triphosphatase activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050728	biological_process	negative regulation of inflammatory response
A	0051150	biological_process	regulation of smooth muscle cell differentiation
A	0055062	biological_process	phosphate ion homeostasis
A	0070667	biological_process	negative regulation of mast cell proliferation
A	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
B	0000166	molecular_function	nucleotide binding
B	0002276	biological_process	basophil activation involved in immune response
B	0003676	molecular_function	nucleic acid binding
B	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B	0004528	molecular_function	phosphodiesterase I activity
B	0004551	molecular_function	dinucleotide phosphatase activity
B	0005509	molecular_function	calcium ion binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009143	biological_process	nucleoside triphosphate catabolic process
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0016324	cellular_component	apical plasma membrane
B	0016462	molecular_function	pyrophosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0030505	biological_process	inorganic diphosphate transport
B	0033007	biological_process	negative regulation of mast cell activation involved in immune response
B	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
B	0036219	molecular_function	GTP diphosphatase activity
B	0036221	molecular_function	UTP diphosphatase activity
B	0046034	biological_process	ATP metabolic process
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0047693	molecular_function	ATP diphosphatase activity
B	0047710	molecular_function	bis(5'-adenosyl)-triphosphatase activity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050728	biological_process	negative regulation of inflammatory response
B	0051150	biological_process	regulation of smooth muscle cell differentiation
B	0055062	biological_process	phosphate ion homeostasis
B	0070667	biological_process	negative regulation of mast cell proliferation
B	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
B	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	0000166	molecular_function	nucleotide binding
C	0002276	biological_process	basophil activation involved in immune response
C	0003676	molecular_function	nucleic acid binding
C	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
C	0004528	molecular_function	phosphodiesterase I activity
C	0004551	molecular_function	dinucleotide phosphatase activity
C	0005509	molecular_function	calcium ion binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0008270	molecular_function	zinc ion binding
C	0009143	biological_process	nucleoside triphosphate catabolic process
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0016324	cellular_component	apical plasma membrane
C	0016462	molecular_function	pyrophosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0030505	biological_process	inorganic diphosphate transport
C	0033007	biological_process	negative regulation of mast cell activation involved in immune response
C	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
C	0036219	molecular_function	GTP diphosphatase activity
C	0036221	molecular_function	UTP diphosphatase activity
C	0046034	biological_process	ATP metabolic process
C	0046872	molecular_function	metal ion binding
C	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
C	0047693	molecular_function	ATP diphosphatase activity
C	0047710	molecular_function	bis(5'-adenosyl)-triphosphatase activity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050728	biological_process	negative regulation of inflammatory response
C	0051150	biological_process	regulation of smooth muscle cell differentiation
C	0055062	biological_process	phosphate ion homeostasis
C	0070667	biological_process	negative regulation of mast cell proliferation
C	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
D	0000166	molecular_function	nucleotide binding
D	0002276	biological_process	basophil activation involved in immune response
D	0003676	molecular_function	nucleic acid binding
D	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
D	0004528	molecular_function	phosphodiesterase I activity
D	0004551	molecular_function	dinucleotide phosphatase activity
D	0005509	molecular_function	calcium ion binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0008270	molecular_function	zinc ion binding
D	0009143	biological_process	nucleoside triphosphate catabolic process
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0016324	cellular_component	apical plasma membrane
D	0016462	molecular_function	pyrophosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0030505	biological_process	inorganic diphosphate transport
D	0033007	biological_process	negative regulation of mast cell activation involved in immune response
D	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
D	0036219	molecular_function	GTP diphosphatase activity
D	0036221	molecular_function	UTP diphosphatase activity
D	0046034	biological_process	ATP metabolic process
D	0046872	molecular_function	metal ion binding
D	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
D	0047693	molecular_function	ATP diphosphatase activity
D	0047710	molecular_function	bis(5'-adenosyl)-triphosphatase activity
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050728	biological_process	negative regulation of inflammatory response
D	0051150	biological_process	regulation of smooth muscle cell differentiation
D	0055062	biological_process	phosphate ion homeostasis
D	0070667	biological_process	negative regulation of mast cell proliferation
D	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
D	0160049	biological_process	negative regulation of cGAS/STING signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdsgCtdrgd.CCwDFedtC

Chain	Residue	Details
A	CYS70-CYS90
A	CYS114-CYS134

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Domain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P15396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	51
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O14638","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	31
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)