6FJ3
High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Parathyroid hormone/parathyroid hormone-related peptide receptor,Parathyroid hormone/parathyroid hormone-related peptide receptor,GlgA glycogen synthase,Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 602 | 68389.2 | 1 | UniProt (Q03431) UniProt (Q9V2J8) Pfam (PF02793) Pfam (PF00002) Pfam (PF13692) | Homo sapiens (Human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor,PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor,Glycogen synthase,PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
| 2 | B (B) | Parathyroid hormone | polymer | 35 | 4277.0 | 1 | UniProt (Q27IM2) Pfam (PF01279) | Equus caballus (Horse) | PTH,Parathyrin |
| 3 | C (C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G82348BZ) | |||
| 4 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | F, G, H (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 3 | Chemie (MAN) | |||
| 7 | I, J, K, L, M... (A) | OLEIC ACID | non-polymer | 282.5 | 9 | Chemie (OLA) | |||
| 8 | R (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 9 | S (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 10 | T (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 11 | U, V (A, B) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: 24 - 60 (UniProt: Q03431)
A: 105 - 388 (UniProt: Q03431)
A: 1218 - 1413 (UniProt: Q9V2J8)
A: 398 - 480 (UniProt: Q03431)
B: 1 - 34 (UniProt: Q27IM2)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Pro 23 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 191 | Tyr 191 | engineered mutation |
| Met 240 | Lys 240 | engineered mutation |
| Ala 300 | Leu 300 | engineered mutation |
| Lys 312 | Met 312 | engineered mutation |
| Ile 334 | Val 334 | engineered mutation |
| Asn 359 | Lys 359 | engineered mutation |
A: 398 - 480 (UniProt: Q03431)
| PDB | External Database | Details |
|---|---|---|
| Ala 407 | Leu 407 | engineered mutation |
| Leu 426 | Ala 426 | engineered mutation |
| Arg 440 | Gln 440 | engineered mutation |
| Ala 458 | Ile 458 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ac5 1 | Ser 32 | conflict |
| Aib 3 | Ser 34 | conflict |
| Gln 10 | Asn 41 | engineered mutation |
| Hrg 11 | Leu 42 | conflict |
| Ala 12 | Gly 43 | engineered mutation |
| Trp 14 | His 45 | engineered mutation |
| Nle 18 | Val 49 | conflict |
| Tyr 34 | Phe 65 | engineered mutation |
| Nh2 35 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72666.2 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2538.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3372.3 | |
| All* | Total formula weight | 78576.9 |
