6FFY

Structure of the mouse SorCS2-NGF complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	VPS10 domain-containing receptor SorCS2	polymer	972	109115.3	1	UniProt (Q9EPR5) Pfam (PF15902) Pfam (PF15901) Pfam (PF00801)	Mus musculus (Mouse)
2	B, C (B, C)	Beta-nerve growth factor	polymer	129	14361.1	2	UniProt (P01139) Pfam (PF00243)	Mus musculus (Mouse)	Beta-NGF
3	D (D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	E, F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A: 116 - 1077 (UniProt: Q9EPR5)

PDB	External Database	Details
Gly 115	-	expression tag
Thr 252	Met 252	conflict
Ala 1078	-	expression tag
Ala 1079	-	expression tag
Ala 1080	-	expression tag
His 1081	-	expression tag
His 1082	-	expression tag
His 1083	-	expression tag
His 1084	-	expression tag
His 1085	-	expression tag
His 1086	-	expression tag

B, C: 122 - 238 (UniProt: P01139)

PDB	External Database	Details
Ala 239	-	expression tag
Ala 240	-	expression tag
Gly 241	-	expression tag
Ala 242	-	expression tag
Ala 243	-	expression tag
Ala 244	-	expression tag
His 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	137837.6
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	139087.7

*Water molecules are not included.