6FFA
FMDV Leader protease bound to substrate ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lbpro | polymer | 167 | 19055.3 | 1 | UniProt (P03305) Pfam (PF05408) | Foot-and-mouth disease virus | |
| 2 | B (B) | Ubiquitin-like protein ISG15 | polymer | 78 | 8810.1 | 1 | UniProt (P05161) Pfam (PF00240) | Homo sapiens (Human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 3 | C, D, E, F, J (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | G, H, I (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A: 29 - 195 (UniProt: P03305)
B: 79 - 155 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Val 126 | Met 126 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 78 | - | initiating methionine |
| Aye 155 | Arg 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27865.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 748.7 | |
| All* | Total formula weight | 28614.1 |
