6FF4
human Bact spliceosome core structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 1 | RNA-binding motif protein, X-linked 2 | polymer | 322 | 37426.0 | 1 | UniProt (Q9Y388) Pfam (PF00076) In PDB | Homo sapiens (Human) | |
| 2 | 2 | U2 snRNA | polymer | 188 | 60186.4 | 1 | GenBank (36516) | Homo sapiens | |
| 3 | 3 | BUD13 homolog | polymer | 619 | 70669.2 | 1 | UniProt (Q9BRD0) Pfam (PF09736) In PDB | Homo sapiens (Human) | |
| 4 | 5 | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens | |
| 5 | 6 | U6 snRNA | polymer | 107 | 34404.4 | 1 | Homo sapiens | ||
| 6 | 7 | Splicing factor 3A subunit 2 | polymer | 464 | 49327.4 | 1 | UniProt (Q15428) Pfam (PF12874) Pfam (PF16835) In PDB | Homo sapiens (Human) | SF3a66,Spliceosome-associated protein 62,SAP 62 |
| 7 | 8 | Splicing factor 3B subunit 2 | polymer | 895 | 100377.8 | 1 | UniProt (Q13435) Pfam (PF02037) Pfam (PF04037) Pfam (PF04046) In PDB | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 145 kDa subunit,SF3b145,Spliceosome-associated protein 145,SAP 145 |
| 8 | A | Pre-mRNA-processing-splicing factor 8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) Pfam (PF08082) Pfam (PF08083) In PDB | Homo sapiens (Human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 9 | B | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 972 | 109560.6 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) In PDB | Homo sapiens (Human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 10 | C | SNW domain-containing protein 1 | polymer | 536 | 61610.7 | 1 | UniProt (Q13573) Pfam (PF02731) In PDB | Homo sapiens (Human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 11 | D | Pleiotropic regulator 1 | polymer | 514 | 57280.8 | 1 | UniProt (O43660) Pfam (PF00400) In PDB | Homo sapiens (Human) | |
| 12 | E | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) In PDB | Homo sapiens (Human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 13 | L | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) In PDB | Homo sapiens (Human) | Cdc5-like protein,Pombe cdc5-related protein |
| 14 | O | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF02184) In PDB | Homo sapiens (Human) | Crooked neck homolog,hCrn |
| 15 | P | Pre-mRNA-splicing factor RBM22 | polymer | 420 | 46959.6 | 1 | UniProt (Q9NW64) Pfam (PF21369) Pfam (PF00076) In PDB | Homo sapiens (Human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
| 16 | Q | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) In PDB | Homo sapiens (Human) | Protein EDG-2,Protein G10 homolog |
| 17 | R | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) In PDB | Homo sapiens (Human) | |
| 18 | S | Serine/arginine repetitive matrix protein 2 | polymer | 2752 | 300255.3 | 1 | UniProt (Q9UQ35) Pfam (PF08312) In PDB | Homo sapiens (Human) | 300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803 |
| 19 | V | Peptidyl-prolyl cis-trans isomerase-like 1 | polymer | 166 | 18257.8 | 1 | UniProt (Q9Y3C6) Pfam (PF00160) In PDB | Homo sapiens (Human) | PPIase,Rotamase PPIL1 |
| 20 | Y | Serine/arginine repetitive matrix protein 1 | polymer | 904 | 102600.5 | 1 | UniProt (Q8IYB3) Pfam (PF01480) In PDB | Homo sapiens (Human) | SR-related nuclear matrix protein of 160 kDa,SRm160,Ser/Arg-related nuclear matrix protein |
| 21 | Z | pre mRNA | polymer | 478 | 153788.0 | 1 | Homo sapiens | ||
| 22 | s | Peptidyl-prolyl cis-trans isomerase CWC27 homolog | polymer | 472 | 53941.2 | 1 | UniProt (Q6UX04) Pfam (PF00160) In PDB | Homo sapiens (Human) | PPIase CWC27,Antigen NY-CO-10,Serologically defined colon cancer antigen 10 |
| 23 | t | RING finger protein 113A | polymer | 343 | 38847.2 | 1 | UniProt (O15541) Pfam (PF00642) Pfam (PF13920) In PDB | Homo sapiens (Human) | Zinc finger protein 183 |
| 24 | u | Splicing factor 3B subunit 1 | polymer | 1304 | 146024.9 | 1 | UniProt (O75533) Pfam (PF08920) In PDB | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155 |
| 25 | v | Splicing factor 3B subunit 3 | polymer | 1217 | 135718.8 | 1 | UniProt (Q15393) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130 |
| 26 | x | Splicing factor 3B subunit 5 | polymer | 86 | 10149.4 | 1 | UniProt (Q9BWJ5) Pfam (PF07189) In PDB | Homo sapiens (Human) | SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| 27 | y | PHD finger-like domain-containing protein 5A | polymer | 110 | 12427.5 | 1 | UniProt (Q7RTV0) Pfam (PF03660) In PDB | Homo sapiens (Human) | PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b |
| 28 | z | Splicing factor 3B subunit 6 | polymer | 125 | 14606.9 | 1 | UniProt (Q9Y3B4) Pfam (PF00076) In PDB | Homo sapiens (Human) | Pre-mRNA branch site protein p14,SF3b 14 kDa subunit,SF3B14a,Spliceosome-associated protein,14-kDa,Splicing factor 3b,subunit 6,14kDa |
| 29 | 6 | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 30 | A | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 31 | B | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 32 | P, Q, t, y | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 2227639.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1934.5 | |
| All* | Total formula weight | 2229574.3 |
