Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FF4

human Bact spliceosome core structure

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000398	biological_process	mRNA splicing, via spliceosome
1	0003676	molecular_function	nucleic acid binding
1	0003723	molecular_function	RNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005686	cellular_component	U2 snRNP
1	0005730	cellular_component	nucleolus
1	0031965	cellular_component	nuclear membrane
1	0071005	cellular_component	U2-type precatalytic spliceosome
1	0071011	cellular_component	precatalytic spliceosome
1	0071013	cellular_component	catalytic step 2 spliceosome
1	1903241	biological_process	U2-type prespliceosome assembly
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0003723	molecular_function	RNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005684	cellular_component	U2-type spliceosomal complex
3	0070274	cellular_component	RES complex
3	0071005	cellular_component	U2-type precatalytic spliceosome
3	1903241	biological_process	U2-type prespliceosome assembly
7	0000245	biological_process	spliceosomal complex assembly
7	0000387	biological_process	spliceosomal snRNP assembly
7	0000389	biological_process	mRNA 3'-splice site recognition
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0003676	molecular_function	nucleic acid binding
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005684	cellular_component	U2-type spliceosomal complex
7	0005686	cellular_component	U2 snRNP
7	0006397	biological_process	mRNA processing
7	0008270	molecular_function	zinc ion binding
7	0010976	biological_process	positive regulation of neuron projection development
7	0016607	cellular_component	nuclear speck
7	0071004	cellular_component	U2-type prespliceosome
7	0071005	cellular_component	U2-type precatalytic spliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	1903241	biological_process	U2-type prespliceosome assembly
8	0000387	biological_process	spliceosomal snRNP assembly
8	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003723	molecular_function	RNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005681	cellular_component	spliceosomal complex
8	0005684	cellular_component	U2-type spliceosomal complex
8	0005686	cellular_component	U2 snRNP
8	0005689	cellular_component	U12-type spliceosomal complex
8	0006397	biological_process	mRNA processing
8	0008380	biological_process	RNA splicing
8	0016607	cellular_component	nuclear speck
8	0071005	cellular_component	U2-type precatalytic spliceosome
8	0071011	cellular_component	precatalytic spliceosome
8	0071013	cellular_component	catalytic step 2 spliceosome
8	1903241	biological_process	U2-type prespliceosome assembly
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0140492	molecular_function	metal-dependent deubiquitinase activity
B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0015030	cellular_component	Cajal body
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0030623	molecular_function	U5 snRNA binding
B	0042220	biological_process	response to cocaine
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	0071466	biological_process	cellular response to xenobiotic stimulus
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003713	molecular_function	transcription coactivator activity
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
C	0016363	cellular_component	nuclear matrix
C	0016607	cellular_component	nuclear speck
C	0016922	molecular_function	nuclear receptor binding
C	0019899	molecular_function	enzyme binding
C	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
C	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	0042809	molecular_function	nuclear vitamin D receptor binding
C	0042974	molecular_function	nuclear retinoic acid receptor binding
C	0043923	biological_process	host-mediated activation of viral transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046332	molecular_function	SMAD binding
C	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
C	0048255	biological_process	mRNA stabilization
C	0048384	biological_process	retinoic acid receptor signaling pathway
C	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
C	0050681	molecular_function	nuclear androgen receptor binding
C	0050769	biological_process	positive regulation of neurogenesis
C	0070562	biological_process	regulation of vitamin D receptor signaling pathway
C	0070564	biological_process	positive regulation of vitamin D receptor signaling pathway
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071300	biological_process	cellular response to retinoic acid
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0000974	cellular_component	Prp19 complex
D	0001650	cellular_component	fibrillar center
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0016607	cellular_component	nuclear speck
D	0031965	cellular_component	nuclear membrane
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0016607	cellular_component	nuclear speck
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	1990403	biological_process	embryonic brain development
L	0000077	biological_process	DNA damage checkpoint signaling
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
L	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
L	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005662	cellular_component	DNA replication factor A complex
L	0005681	cellular_component	spliceosomal complex
L	0005737	cellular_component	cytoplasm
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0016020	cellular_component	membrane
L	0016607	cellular_component	nuclear speck
L	0019904	molecular_function	protein domain specific binding
L	0042802	molecular_function	identical protein binding
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0071007	cellular_component	U2-type catalytic step 2 spliceosome
L	0071013	cellular_component	catalytic step 2 spliceosome
L	0071987	molecular_function	WD40-repeat domain binding
O	0000245	biological_process	spliceosomal complex assembly
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0006396	biological_process	RNA processing
O	0016607	cellular_component	nuclear speck
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0071014	cellular_component	post-mRNA release spliceosomal complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0017070	molecular_function	U6 snRNA binding
P	0033120	biological_process	positive regulation of RNA splicing
P	0036002	molecular_function	pre-mRNA binding
P	0042307	biological_process	positive regulation of protein import into nucleus
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0046827	biological_process	positive regulation of protein export from nucleus
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0071006	cellular_component	U2-type catalytic step 1 spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0071466	biological_process	cellular response to xenobiotic stimulus
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000785	cellular_component	chromatin
Q	0003713	molecular_function	transcription coactivator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0016922	molecular_function	nuclear receptor binding
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0016607	cellular_component	nuclear speck
R	0045292	biological_process	mRNA cis splicing, via spliceosome
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000413	biological_process	protein peptidyl-prolyl isomerization
s	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0006457	biological_process	protein folding
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0003729	molecular_function	mRNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0070742	molecular_function	C2H2 zinc finger domain binding
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005684	cellular_component	U2-type spliceosomal complex
t	0016567	biological_process	protein ubiquitination
t	0016607	cellular_component	nuclear speck
t	0046872	molecular_function	metal ion binding
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070100	biological_process	negative regulation of chemokine-mediated signaling pathway
t	0071005	cellular_component	U2-type precatalytic spliceosome
u	0000245	biological_process	spliceosomal complex assembly
u	0000375	biological_process	RNA splicing, via transesterification reactions
u	0000387	biological_process	spliceosomal snRNP assembly
u	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000785	cellular_component	chromatin
u	0003723	molecular_function	RNA binding
u	0003729	molecular_function	mRNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005684	cellular_component	U2-type spliceosomal complex
u	0005686	cellular_component	U2 snRNP
u	0005689	cellular_component	U12-type spliceosomal complex
u	0005730	cellular_component	nucleolus
u	0006338	biological_process	chromatin remodeling
u	0008380	biological_process	RNA splicing
u	0016607	cellular_component	nuclear speck
u	0031981	cellular_component	nuclear lumen
u	0034693	cellular_component	U11/U12 snRNP
u	0036002	molecular_function	pre-mRNA binding
u	0045292	biological_process	mRNA cis splicing, via spliceosome
u	0045943	biological_process	positive regulation of transcription by RNA polymerase I
u	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0045945	biological_process	positive regulation of transcription by RNA polymerase III
u	0071004	cellular_component	U2-type prespliceosome
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	1903241	biological_process	U2-type prespliceosome assembly
u	1990935	molecular_function	splicing factor binding
v	0000375	biological_process	RNA splicing, via transesterification reactions
v	0000387	biological_process	spliceosomal snRNP assembly
v	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0003676	molecular_function	nucleic acid binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005684	cellular_component	U2-type spliceosomal complex
v	0005686	cellular_component	U2 snRNP
v	0005689	cellular_component	U12-type spliceosomal complex
v	0005730	cellular_component	nucleolus
v	0006282	biological_process	regulation of DNA repair
v	0008380	biological_process	RNA splicing
v	0030620	molecular_function	U2 snRNA binding
v	0042177	biological_process	negative regulation of protein catabolic process
v	0043484	biological_process	regulation of RNA splicing
v	0044877	molecular_function	protein-containing complex binding
v	0045893	biological_process	positive regulation of DNA-templated transcription
v	0071005	cellular_component	U2-type precatalytic spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
v	1903241	biological_process	U2-type prespliceosome assembly
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0000413	biological_process	protein peptidyl-prolyl isomerization
V	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005730	cellular_component	nucleolus
V	0006457	biological_process	protein folding
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	0097718	molecular_function	disordered domain specific binding
V	1990403	biological_process	embryonic brain development
x	0000387	biological_process	spliceosomal snRNP assembly
x	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005684	cellular_component	U2-type spliceosomal complex
x	0005686	cellular_component	U2 snRNP
x	0005689	cellular_component	U12-type spliceosomal complex
x	0006282	biological_process	regulation of DNA repair
x	0043484	biological_process	regulation of RNA splicing
x	0045893	biological_process	positive regulation of DNA-templated transcription
x	0071005	cellular_component	U2-type precatalytic spliceosome
x	0071011	cellular_component	precatalytic spliceosome
x	1903241	biological_process	U2-type prespliceosome assembly
x	1990935	molecular_function	splicing factor binding
y	0000387	biological_process	spliceosomal snRNP assembly
y	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0003723	molecular_function	RNA binding
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005684	cellular_component	U2-type spliceosomal complex
y	0005686	cellular_component	U2 snRNP
y	0005689	cellular_component	U12-type spliceosomal complex
y	0008270	molecular_function	zinc ion binding
y	0016363	cellular_component	nuclear matrix
y	0016607	cellular_component	nuclear speck
y	0045893	biological_process	positive regulation of DNA-templated transcription
y	0048863	biological_process	stem cell differentiation
y	0071005	cellular_component	U2-type precatalytic spliceosome
y	0071011	cellular_component	precatalytic spliceosome
y	0071013	cellular_component	catalytic step 2 spliceosome
y	1903241	biological_process	U2-type prespliceosome assembly
Y	0000375	biological_process	RNA splicing, via transesterification reactions
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005681	cellular_component	spliceosomal complex
Y	0005829	cellular_component	cytosol
Y	0008380	biological_process	RNA splicing
Y	0016363	cellular_component	nuclear matrix
Y	0016607	cellular_component	nuclear speck
Y	0048024	biological_process	regulation of mRNA splicing, via spliceosome
Y	0071013	cellular_component	catalytic step 2 spliceosome
z	0000387	biological_process	spliceosomal snRNP assembly
z	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
z	0000398	biological_process	mRNA splicing, via spliceosome
z	0003676	molecular_function	nucleic acid binding
z	0003723	molecular_function	RNA binding
z	0003729	molecular_function	mRNA binding
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005684	cellular_component	U2-type spliceosomal complex
z	0005689	cellular_component	U12-type spliceosomal complex
z	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG 6 201

Chain	Residue
6	A53
6	G54
6	U74

site_id	AC2
Number of Residues	1
Details	binding site for residue MG 6 202

Chain	Residue
6	G75

site_id	AC3
Number of Residues	1
Details	binding site for residue MG 6 203

Chain	Residue
6	G75

site_id	AC4
Number of Residues	2
Details	binding site for residue MG 6 204

Chain	Residue
6	C55
6	G71

site_id	AC5
Number of Residues	9
Details	binding site for residue IHP A 3001

Chain	Residue
A	HIS584
A	LYS609
A	HIS610
A	TYR613
A	TYR614
A	LYS623
t	ARG179
A	ARG163
A	LYS442

site_id	AC6
Number of Residues	19
Details	binding site for residue GTP B 1500

Chain	Residue
B	LEU138
B	HIS139
B	HIS140
B	GLY141
B	LYS142
B	THR143
B	CYS144
B	ASP164
B	CYS166
B	ASP169
B	VAL179
B	GLY207
B	ASN258
B	LYS259
B	ASP261
B	ARG262
B	SER311
B	SER312
B	GLN313

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN P 501

Chain	Residue
P	CYS24
P	CYS27
P	CYS81
P	CYS84

site_id	AC8
Number of Residues	3
Details	binding site for residue ZN P 502

Chain	Residue
P	CYS165
P	CYS173
P	CYS179

site_id	AC9
Number of Residues	5
Details	binding site for residue ZN P 503

Chain	Residue
P	CYS45
P	CYS48
P	CYS71
P	CYS74
P	GLN119

site_id	AD1
Number of Residues	3
Details	binding site for residue ZN Q 201

Chain	Residue
Q	CYS101
Q	CYS102
Q	CYS137

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN Q 202

Chain	Residue
Q	LEU100
Q	CYS101
Q	CYS119
Q	ARG140

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN Q 203

Chain	Residue
Q	CYS105
Q	CYS117
Q	CYS119
Q	CYS134

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN t 401

Chain	Residue
t	CYS202
t	CYS211
t	CYS217
t	HIS221

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN y 201

Chain	Residue
y	CYS11
y	CYS46
y	CYS49
y	CYS85

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN y 202

Chain	Residue
y	CYS23
y	CYS26
y	CYS58
y	CYS61

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN y 203

Chain	Residue
y	CYS30
y	CYS33
y	CYS72
y	CYS75

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YdnTiFHRVVpgFIvQGG

Chain	Residue	Details
s	TYR49-GLY66
V	TYR48-GLY65

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
v	PHE287-HIS293

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHyFCesCA

Chain	Residue	Details
t	CYS277-ALA286

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSCsmDcKIKLWEV

Chain	Residue	Details
E	LEU304-VAL318
D	LEU303-VAL317
D	ILE345-LEU359

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
Q	LEU100-PRO122

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
Q	CYS134-SER143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	226
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	30
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	50
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q62203","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	273
Details	Region: {"description":"Linker"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	40
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	38
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	39
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	51
Details	Domain: {"description":"HTH myb-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	45
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	32
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	31
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	31
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	35
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	34
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	55
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	8
Details	Region: {"description":"Interaction with AR","evidences":[{"source":"PubMed","id":"28076346","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9JHS9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Heiserich L.","Boulahbel H.","Gottlieb E."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	309
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16595688","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	38
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	34
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	38
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	38
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	38
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	39
Details	Region: {"description":"Interaction with SF3B14"}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	4
Details	Region: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	8
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	1
Details	Site: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI71
Number of Residues	4
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI72
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI74
Number of Residues	37
Details	Region: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI75
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI76
Number of Residues	21
Details	Region: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI77
Number of Residues	23
Details	Region: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI78
Number of Residues	5
Details	Site: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI79
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI80
Number of Residues	77
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI81
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI82
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI83
Number of Residues	3
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI84
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI85
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P83870","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI86
Number of Residues	13
Details	Region: {"description":"Interaction with pre-mRNA branch site"}

Chain

Residue

Details

site_id	SWS_FT_FI87
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI88
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)