6F8X
Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 343 | 39624.9 | 2 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, B | 2-[(5~{R})-3-(3-cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-1,2-oxazol-5-yl]-~{N},~{N}-bis(2-hydroxyethyl)ethanamide | non-polymer | 406.5 | 2 | Chemie (D08) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
6 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
7 | water | water | 18.0 | 455 | Chemie (HOH) |
Sequence modifications
A, B: 244 - 579 (UniProt: Q08499)
PDB | External Database | Details |
---|---|---|
Met 243 | - | initiating methionine |
Ala 579 | Ser 579 | conflict |
His 580 | - | expression tag |
His 581 | - | expression tag |
His 582 | - | expression tag |
His 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79249.9 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1243.3 | |
All* | Total formula weight | 80493.1 |