6F8X
Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | HIS330 |
| A | HIS366 |
| A | ASP367 |
| A | ASP484 |
| A | HOH725 |
| A | HOH835 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | HOH814 |
| A | HOH838 |
| A | HOH860 |
| A | ASP367 |
| A | HOH725 |
| A | HOH801 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | ASN417 |
| A | HOH704 |
| A | HOH813 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | ASP467 |
| A | ASP471 |
| A | HIS527 |
| A | HOH755 |
| A | HOH769 |
| A | HOH782 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue D08 A 605 |
| Chain | Residue |
| A | TYR325 |
| A | HIS326 |
| A | SER374 |
| A | ASN375 |
| A | MET439 |
| A | ASN487 |
| A | ILE502 |
| A | MET503 |
| A | PHE506 |
| A | MET523 |
| A | SER534 |
| A | GLN535 |
| A | PHE538 |
| A | EDO606 |
| A | HOH702 |
| A | HOH724 |
| A | HOH735 |
| A | HOH780 |
| A | HOH789 |
| A | HOH791 |
| A | HOH846 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | GLN509 |
| A | PRO522 |
| A | CYS524 |
| A | D08605 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | SER461 |
| A | GLY462 |
| A | VAL554 |
| A | HIS555 |
| A | ASP557 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | HIS330 |
| B | HIS366 |
| B | ASP367 |
| B | ASP484 |
| B | MG602 |
| B | HOH758 |
| B | HOH786 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 602 |
| Chain | Residue |
| B | ASP367 |
| B | ZN601 |
| B | HOH758 |
| B | HOH765 |
| B | HOH796 |
| B | HOH804 |
| B | HOH837 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 603 |
| Chain | Residue |
| A | ASP567 |
| A | HOH799 |
| A | HOH842 |
| B | ASP540 |
| B | HIS544 |
| B | PRO545 |
| B | GLU548 |
| site_id | AD2 |
| Number of Residues | 21 |
| Details | binding site for residue D08 B 604 |
| Chain | Residue |
| B | TYR325 |
| B | HIS326 |
| B | SER374 |
| B | ASN375 |
| B | MET439 |
| B | ASN487 |
| B | THR499 |
| B | ILE502 |
| B | MET503 |
| B | MET523 |
| B | SER534 |
| B | GLN535 |
| B | PHE538 |
| B | HOH705 |
| B | HOH731 |
| B | HOH745 |
| B | HOH748 |
| B | HOH762 |
| B | HOH789 |
| B | HOH798 |
| B | HOH811 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS366-PHE377 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
