6F8X

Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 601

Chain	Residue
A	HIS330
A	HIS366
A	ASP367
A	ASP484
A	HOH725
A	HOH835

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 602

Chain	Residue
A	HOH814
A	HOH838
A	HOH860
A	ASP367
A	HOH725
A	HOH801

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 603

Chain	Residue
A	ASN417
A	HOH704
A	HOH813

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	ASP467
A	ASP471
A	HIS527
A	HOH755
A	HOH769
A	HOH782

---

site_id	AC5
Number of Residues	21
Details	binding site for residue D08 A 605

Chain	Residue
A	TYR325
A	HIS326
A	SER374
A	ASN375
A	MET439
A	ASN487
A	ILE502
A	MET503
A	PHE506
A	MET523
A	SER534
A	GLN535
A	PHE538
A	EDO606
A	HOH702
A	HOH724
A	HOH735
A	HOH780
A	HOH789
A	HOH791
A	HOH846

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 606

Chain	Residue
A	GLN509
A	PRO522
A	CYS524
A	D08605

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 607

Chain	Residue
A	SER461
A	GLY462
A	VAL554
A	HIS555
A	ASP557

---

site_id	AC8
Number of Residues	7
Details	binding site for residue ZN B 601

Chain	Residue
B	HIS330
B	HIS366
B	ASP367
B	ASP484
B	MG602
B	HOH758
B	HOH786

---

site_id	AC9
Number of Residues	7
Details	binding site for residue MG B 602

Chain	Residue
B	ASP367
B	ZN601
B	HOH758
B	HOH765
B	HOH796
B	HOH804
B	HOH837

---

site_id	AD1
Number of Residues	7
Details	binding site for residue DMS B 603

Chain	Residue
A	ASP567
A	HOH799
A	HOH842
B	ASP540
B	HIS544
B	PRO545
B	GLU548

---

site_id	AD2
Number of Residues	21
Details	binding site for residue D08 B 604

Chain	Residue
B	TYR325
B	HIS326
B	SER374
B	ASN375
B	MET439
B	ASN487
B	THR499
B	ILE502
B	MET503
B	MET523
B	SER534
B	GLN535
B	PHE538
B	HOH705
B	HOH731
B	HOH745
B	HOH748
B	HOH762
B	HOH789
B	HOH798
B	HOH811

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343

Chain	Residue	Details
A	GLY462
B	GLY462

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7

Chain	Residue	Details
A	GLY462
B	GLY462

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3

Chain	Residue	Details
A	LEU466
B	LEU466

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3

Chain	Residue	Details
A	ILE502
B	ILE502

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW

Chain	Residue	Details
A	MET503
B	MET503

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	LYS299
A	PHE301
B	LYS299
B	PHE301

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU348
A	ASN375
B	GLU348
B	ASN375

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Chain	Residue	Details
A	LEU387
B	LEU387

---