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6F8T

Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcAMP-specific 3',5'-cyclic phosphodiesterase 4Dpolymer34339624.92UniProt (Q08499)
Pfam (PF00233)
In PDB
Homo sapiens (Human)DPDE3,PDE43
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, BMAGNESIUM IONnon-polymer24.35Chemie (MG)
4A, B(2~{R})-1-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-3-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]propan-2-olnon-polymer406.52Chemie (CZT)
5waterwater18.0624Chemie (HOH)
Sequence modifications
A, B: 244 - 578 (UniProt: Q08499)
PDBExternal DatabaseDetails
Met 243-initiating methionine
Ala 579-expression tag
His 580-expression tag
His 581-expression tag
His 582-expression tag
His 583-expression tag
His 584-expression tag
His 585-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79249.9
Non-Polymers*Number of molecules9
Total formula weight1065.4
All*Total formula weight80315.3
*Water molecules are not included.

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PDB entries from 2024-03-27

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