6F59
Crystal structure of human Brachyury (T) G177D variant in complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (C, D) | DNA (26-MER) | polymer | 26 | 7986.2 | 2 | Homo sapiens | ||
| 2 | C, D (A, B) | Brachyury protein | polymer | 192 | 22080.4 | 2 | UniProt (O15178) Pfam (PF00907) | Homo sapiens (Human) | Protein T |
| 3 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 5 | G, H, I, J (C, D, A, B) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A, B: 41 - 224 (UniProt: O15178)
| PDB | External Database | Details |
|---|---|---|
| Met 39 | - | initiating methionine |
| Gly 40 | - | expression tag |
| Asp 177 | Gly 177 | conflict |
| His 225 | - | expression tag |
| His 226 | - | expression tag |
| His 227 | - | expression tag |
| His 228 | - | expression tag |
| His 229 | - | expression tag |
| His 230 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60133.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 141.2 | |
| All* | Total formula weight | 60274.3 |
