6F58

Crystal structure of human Brachyury (T) in complex with DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, D	DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3')	polymer	24	7367.8	2		Homo sapiens
2	A, B	Brachyury protein	polymer	192	22022.4	2	UniProt (O15178) Pfam (PF00907) In PDB	Homo sapiens (Human)	Protein T
3	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4		water	water		18.0	335	Chemie (HOH)

Sequence modifications

A, B: 39 - 224 (UniProt: O15178)

PDB	External Database	Details
Met 39	Glu 39	initiating methionine
Gly 40	Arg 40	conflict
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	58780.3
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	58803.3

*Water molecules are not included.