6F58

Crystal structure of human Brachyury (T) in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 301

Chain	Residue
A	LYS66
A	THR149
A	LYS151
A	ASN153
A	GLN157

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Functional Information from PROSITE/UniProt

site_id	PS01264
Number of Residues	19
Details	TBOX_2 T-box domain signature 2. IHPDSpnfGahWMkapVsF

Chain	Residue	Details
A	ILE125-PHE143

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site_id	PS01283
Number of Residues	20
Details	TBOX_1 T-box domain signature 1. LWlrFkeltNEMIVTknGRR

Chain	Residue	Details
A	LEU51-ARG70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	336
Details	DNA_BIND: T-box => ECO:0000255|PROSITE-ProRule:PRU00201

Chain	Residue	Details
A	LEU51-ASP219
B	LEU51-ASP219

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