6ERG

Complex of XLF and heterodimer Ku bound to DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	X-ray repair cross-complementing protein 6	polymer	544	62629.6	2	UniProt (P12956) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) In PDB	Homo sapiens (Human)	5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
2	B, E	X-ray repair cross-complementing protein 5	polymer	572	65356.8	2	UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) In PDB	Homo sapiens (Human)	86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
3	C, F	Non-homologous end-joining factor 1	polymer	13	1536.9	2	UniProt (Q9H9Q4) In PDB	Homo sapiens	Protein cernunnos,XRCC4-like factor
4	H, K	DNA (21-MER)	polymer	21	6506.2	2		Synthetic construct
5	M, R	DNA (34-MER)	polymer	34	10325.7	2		Synthetic construct
6	B, D, E	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7		water	water		18.0	20	Chemie (HOH)

Sequence modifications

B, E: 2 - 555 (UniProt: P13010)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	292710.5
Non-Polymers*	Number of molecules	3
	Total formula weight	288.2
All*	Total formula weight	292998.7

*Water molecules are not included.