6EN4
SF3b core in complex with a splicing modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Splicing factor 3B subunit 3 | polymer | 1209 | 135019.0 | 1 | UniProt (Q15393) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178) | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130 |
| 2 | B (B) | Splicing factor 3B subunit 5 | polymer | 85 | 10018.2 | 1 | UniProt (Q9BWJ5) Pfam (PF07189) | Homo sapiens (Human) | SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| 3 | C (C) | Splicing factor 3B subunit 1 | polymer | 852 | 96615.7 | 1 | UniProt (O75533) Pfam (PF22646) | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155 |
| 4 | D (D) | PHD finger-like domain-containing protein 5A | polymer | 108 | 11670.5 | 1 | UniProt (Q7RTV0) Pfam (PF03660) | Homo sapiens (Human) | PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b |
| 5 | E, F, G (D) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | H (D) | [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{S})-6-methyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate | non-polymer | 536.7 | 1 | Chemie (BGZ) PubChem (22185946) PubChem (59444786) PubChem (89363004) PubChem (90909513) PubChem (88973800) PubChem (91176837) PubChem (91569880) PubChem (102340760) PubChem (9807215) PubChem (146158907) PubChem (131854031) PubChem (133562760) PubChem (156593964) PubChem (163060861) PubChem (163060862) PubChem (163060863) PubChem (163285967) PubChem (166639867) PubChem (172014069) PubChem (16202130) |
Sequence modifications
A: 1 - 1199 (UniProt: Q15393)
D: 1 - 98 (UniProt: Q7RTV0)
| PDB | External Database | Details |
|---|---|---|
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
| - | Glu 1068 | deletion |
| - | Asp 1069 | deletion |
| - | Pro 1070 | deletion |
| - | Thr 1071 | deletion |
| - | Gly 1072 | deletion |
| - | Asn 1073 | deletion |
| - | Lys 1074 | deletion |
| - | Ala 1075 | deletion |
| - | Leu 1076 | deletion |
| - | Trp 1077 | deletion |
| - | Asp 1078 | deletion |
| - | Arg 1079 | deletion |
| - | Gly 1080 | deletion |
| - | Leu 1081 | deletion |
| - | Leu 1082 | deletion |
| - | Asn 1083 | deletion |
| - | Gly 1084 | deletion |
| - | Ala 1085 | deletion |
| Asp 1200 | - | expression tag |
| Tyr 1201 | - | expression tag |
| Lys 1202 | - | expression tag |
| Asp 1203 | - | expression tag |
| Asp 1204 | - | expression tag |
| Asp 1205 | - | expression tag |
| Asp 1206 | - | expression tag |
| Lys 1207 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 253323.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 732.9 | |
| All* | Total formula weight | 254056.3 |
