6EN4

SF3b core in complex with a splicing modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000124	cellular_component	SAGA complex
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005684	cellular_component	U2-type spliceosomal complex
A	0005686	cellular_component	U2 snRNP
A	0005689	cellular_component	U12-type spliceosomal complex
A	0005730	cellular_component	nucleolus
A	0006282	biological_process	regulation of DNA repair
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0030620	molecular_function	U2 snRNA binding
A	0042177	biological_process	negative regulation of protein catabolic process
A	0043484	biological_process	regulation of RNA splicing
A	0044877	molecular_function	protein-containing complex binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	1903241	biological_process	U2-type prespliceosome assembly
B	0000124	cellular_component	SAGA complex
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005686	cellular_component	U2 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0006282	biological_process	regulation of DNA repair
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0043484	biological_process	regulation of RNA splicing
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly
B	1990935	molecular_function	splicing factor binding
C	0000245	biological_process	spliceosomal complex assembly
C	0003729	molecular_function	mRNA binding
D	0000398	biological_process	mRNA splicing, via spliceosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN D 101

Chain	Residue
D	CYS30
D	CYS33
D	CYS72
D	CYS75

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 102

Chain	Residue
D	CYS23
D	CYS26
D	CYS58
D	CYS61

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 103

Chain	Residue
D	CYS46
D	CYS49
D	CYS85
D	CYS11

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site_id	AC4
Number of Residues	12
Details	binding site for residue BGZ D 104

Chain	Residue
C	LEU1066
C	LYS1071
C	ARG1074
C	ARG1075
C	VAL1078
C	VAL1110
C	VAL1114
C	PHE1153
C	TYR1157
D	TYR36
D	VAL37
D	ARG38

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
A	PHE287-HIS293

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:28541300, ECO:0007744|PDB:5IFE, ECO:0007744|PDB:5SYB

Chain	Residue	Details
D	CYS11
D	CYS72
D	CYS75
D	CYS85
D	CYS23
D	CYS26
D	CYS30
D	CYS33
D	CYS46
D	CYS49
D	CYS58
D	CYS61

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with SF3B3 => ECO:0000269|PubMed:27720643

Chain	Residue	Details
D	VAL17
A	LYS1171

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P83870

Chain	Residue	Details
D	ALA2
C	CYS677
C	GLU1205

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
D	LYS3

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER94
C	LYS562

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