6EJ0

Crystal structure of KDM5B in complex with KDOPZ000049a.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lysine-specific demethylase 5B,Lysine-specific demethylase 5B	polymer	458	52854.6	1	UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) In PDB	Homo sapiens (Human)	Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	A	DIMETHYL SULFOXIDE	non-polymer		78.1	5	Chemie (DMS)
6	A	7-oxidanylidene-6-propan-2-yl-5-[1-(1-prop-2-enoylpiperidin-4-yl)pyrazol-4-yl]-6~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile	non-polymer		405.5	1	Chemie (B7K)
7		water	water		18.0	177	Chemie (HOH)

Sequence modifications

A: 26 - 98 (UniProt: Q9UGL1)

PDB	External Database	Details
Met 25	-	initiating methionine

A: 375 - 754 (UniProt: Q9UGL1)

PDB	External Database	Details
Gly 371	-	linker
Gly 372	-	linker
Gly 373	-	linker
Gly 374	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52854.6
Non-Polymers*	Number of molecules	11
	Total formula weight	1095.5
All*	Total formula weight	53950.2

*Water molecules are not included.