6EG8
Structure of the GDP-bound Gs heterotrimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D, F | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 4 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
2 | C, E, G, H | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 4 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
3 | I, J, K, L | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 381 | 44333.1 | 4 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
4 | I, J, K, L | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
5 | I, J, K, L | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
6 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B, D, F: 2 - 340 (UniProt: P62873)
C, E, G, H: 1 - 71 (UniProt: P59768)
I, J, K, L: 4 - 394 (UniProt: P63092)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 68 | Cys 68 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Gly 2 | - | expression tag |
Ser 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 359625.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1870.0 | |
All* | Total formula weight | 361495.2 |