6EG8
Structure of the GDP-bound Gs heterotrimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, F (A, B, D, F) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 4 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 2 | C, E, G, H (C, E, G, H) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 4 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 3 | I, J, K, L (I, J, K, L) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 381 | 44333.1 | 4 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 4 | M, O, Q, S (I, J, K, L) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) PubChem (136073927) | |||
| 5 | N, P, R, T (I, J, K, L) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 6 | AA, BA, CA, U, V... (J, K, L, A, B...) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B, D, F: 2 - 340 (UniProt: P62873)
C, E, G, H: 1 - 71 (UniProt: P59768)
I, J, K, L: 4 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 359625.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1870.0 | |
| All* | Total formula weight | 361495.2 |
